Results 101 to 110 of about 251,912 (281)

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Thioredoxin-related Protein 32 (TRP32) Specifically Reduces Oxidized Phosphatase of Regenerating Liver (PRL)*

Journal of Biological Chemistry, 2013
Background: Phosphatase of regenerating liver (PRL) is a metastasis-associated protein that is susceptible to inactivation by oxidation. Results: Thioredoxin-related protein 32 (TRP32) specifically binds and reduces oxidized PRL.
Tasuku Ishii, Y. Funato, H. Miki
semanticscholar   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

„Cała Polska stoi dziś w kolejkach". Powieści Konwickiego jako źródło do badania codzienności PRL-u

Litteraria Copernicana, 2008
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Piotr Perkowski
doaj   +1 more source

Reply to the comment by Jacobs and Thorpe

, 1998
Reply to a comment on "Infinite-Cluster geometry in central-force networks", PRL 78 (1997), 1480.
C. Moukarzel, C. Moukarzel, C. Moukarzel, C. Moukarzel, D. Jacobs, D. Jacobs, D. Jacobs, P. L. Leath, P. M. Duxbury   +8 more
core   +1 more source

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang, Fengqin Wang, Lanlan Liu, Qi Zhang, Xiaoning Huo, Yanhui Nan, Yanli Dong, Yunling Xiao, Jing Hao   +8 more
wiley   +1 more source

Relacje polsko-austriackie u schyłku zimnej wojny w świetle polskich źródeł dyplomatycznych

Przegląd Nauk Historycznych
Przyjęte metody badań historycznych miały za zadanie odpowiedzieć na pytanie, czy państwa wschodnie sąsiadujące z Austrią, ograniczone swym systemem gospodarczym i politycznym, mogły liczyć na pomoc w zakresie inicjowania reform politycznych ...
Agnieszka Kisztelińska-Węgrzyńska
doaj   +1 more source

Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma

Journal of Translational Medicine, 2013
PRL-3 is a member of phosphatases of regenerating liver family, characterized by phosphatase active domain and C-terminal prenylation motif. Overexpression of PRL-3 has been implicated in multiple cancers.
Xiaofang Xing, S. Lian, Ying Hu, Ziyu Li, Lianhai Zhang, X. Wen, H. Du, Yongning Jia, ZhiXue Zheng, L. Meng, C. Shou, J. Ji   +11 more
semanticscholar   +1 more source

Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs

The Anatomical Record, EarlyView.
Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy, Alice Nishigaki, Matthew C. Gage, Renato L. Previdelli   +3 more
wiley   +1 more source

Characterization of Chicken Prolactin Regulatory Element Binding Protein and its Expression in the Anterior Pituitary Gland during Embryogenesis and Different Reproductive Stages

The Journal of Poultry Science, 2015
The PRL regulatory element binding protein (PREB) is a transcription factor that specifically binds to a Pit-1 binding element in the PRL promoter to regulate PRL gene expression in mammals.
Gen Hiyama, Norio Kansaku, Toshio Tanaka, Shin Wakui, David Zadworny   +4 more
doaj   +1 more source