Results 111 to 120 of about 8,519 (204)

Targeting PRMT5 alleviates diabetic cardiomyopathy: mechanisms involve Ndufs2 R118 dimethylation-mediated complex I protection and serum PRMT5 as a biomarker

Background Diabetic cardiomyopathy (DCM) is defined by progressive cardiac dysfunction driven by myocardial ATP depletion, where mitochondrial electron transport chain (ETC) Complex I dysfunction acts as a critical factor.
Jing Li, Run Wang, Jie Huang, Min Wu, Yang Yu, Cong Chen, Qingxia Lai, Mingya Liu, Kai-Hang Yiu, Mengqi Su, Sidong Cai   +10 more
core   +1 more source

C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling

The Journal of Clinical Investigation
Protein arginine methyltransferase 5 (PRMT5) complexes with methylosome protein 50 (MEP50) play crucial roles in tumor progress. However, the regulatory mechanism of governing the PRMT5-MEP50 hetero-octameric complex remains unclear. Here, we demonstrate
Yufeng Qiao, Zhenzhen Wu, Peng Wang, Yiliang Jin, Furong Bai, Fei Zhang, Yunhe An, Meiying Xue, Han Feng, Yong Zhang, Yaxin Hou, Junfeng Du, Huiyun Cai, Guizhi Shi, Bing Zhou, Pu Gao, Jizhong Lou, Peng Zhang, Kelong Fan, Jinbo Liu, Pengcheng Bu   +20 more
doaj   +1 more source

Matrix‑stiffness‑triggered mechanotransduction fuels hepatocellular carcinoma proliferation through Hippo‑orchestrated ANKRD1‑PRMT5 complex‑driven arginine methylome remodeling. [PDF]

Mil Med Res
Huang JC, Chen BD, Xu Y, Zheng SJ, Hu YQ, Pan CX, Zhu LZ, Chi Y, Wang ML, Wang F, Hua YX, Gong PY, Chen JX, Zheng SS, Qiao YT.   +14 more
europepmc   +1 more source

PRMT5 promotes ferroptosis in cisplatin-induced acute kidney injury through WDR5/ACSL4 pathway. [PDF]

Redox Biol
Lin J, Fang J, Cui T, Xu J, Lin W, Li S, Sui Y, Zheng Z, Wu K, Huang M.   +9 more
europepmc   +1 more source

Role of PRMT5 in regulating ferritinophagy during Mycobacterium tuberculosis infection. [PDF]

PLoS Pathog
Sundar S, Rajmani RS, Balaji KN.
europepmc   +1 more source

MTAP Loss and Pleural Mesothelioma (PM): Current Treatment Strategies and Emerging Therapeutic Approaches. [PDF]

Cancers (Basel)
Cedres S, Masfarre L, Priano I, Valdivia A, Rocha P, Iranzo P, Pardo N, Martinez-Marti A, Arbusà A, Cane L, Soleda M, Sinigaglia B, Polo-Alonso S, Romero-Sola G, Caro-Consuegra R, Ortega A, Felip E.   +16 more
europepmc   +1 more source

Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment. [PDF]

J Enzyme Inhib Med Chem
Chi Z, Xu X, Shen Z, Deng X, Elzey BD, Li C, Jiang W, Hu CD.   +7 more
europepmc   +1 more source

Targeting PRMT5 with indole-based arylsulfonylhydrazides: a novel epigenetic strategy for the treatment of acute and chronic leukemia. [PDF]

Am J Cancer Res
Lin J, Gill OBQ, Zheng S, Niu R, Hong L, Teng Y.   +5 more
europepmc   +1 more source

S-Adenosylmethionine-Dependent Methylation, Protein Arginine Methyltransferases and Cardiovascular Diseases. [PDF]

Biomolecules
Yan Z, Zhao W, Zhao N, Li J.
europepmc   +1 more source

Methylosome and survival motor neuron complexes are dispensable for plant viability in Arabidopsis thaliana. [PDF]

Plant Physiol
Goretti D, Collani S, Nardeli SM, Ratnakaram H, Robert S, Schmid M.   +5 more
europepmc   +1 more source