Results 101 to 110 of about 8,519 (204)

PRMT5 Mediates SREBP1 Independent Hepatic Signaling Networks in Lipid Homeostasis

, 2018
PRMT5's regulation of SREBP1 expression in hepatocytes was investigated in the context of NAFLD. Depleting PRMT5 expression by shRNA mediated gene silencing or inhibiting its enzymatic activity by a small molecule inhibitor decreased SREBP1 expression on
Sibley, Katelyne Jean
core   +2 more sources

Abstracts of 14th International Symposium on Hodgkin Lymphoma

HemaSphere, Volume 10, Issue S2, October 2026.
wiley   +1 more source

High PRMT5 levels, maintained by KEAP1 inhibition, drive chemoresistance in high-grade serous ovarian cancer

The Journal of Clinical Investigation
Protein arginine methyl transferases (PRMTs) are generally upregulated in cancers. However, the mechanisms leading to this upregulation and its biological consequences are poorly understood.
Harun Ozturk, Fidan Seker-Polat, Neda Abbaszadeh, Yasemin Kingham, Sandra Orsulic, Mazhar Adli   +5 more
doaj   +1 more source

PRMT5-mediated regulation of developmental myelination [PDF]

, 2018
Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous system. They are derived from differentiation of oligodendrocyte progenitors through a process requiring cell cycle exit and histone modifications.
Canoll, Peter, Casaccia, Patricia, Bok, Jabez, Yattah, Camila, Mela, Angeliki, Zhou, Ting, Teo, Shun Xie, Guccione, Ernesto, Zhang, Jingxian, Scaglione, Antonella, Patzig, Julia, Bernstein, Emily, Frawley, Rebecca, Liang, Jialiang, Chen, Shuibing   +14 more
core  

PRMT5-MEP50 overall structure.

, 2013
A. PRMT5-MEP50 tetrameric surface-filled model. The dimer of PRMT5 molecules is arranged in a head-to-tail form (dark blue and purple). MEP50 is bound to the N-terminus of each PRMT5 molecule on the oblong face of the WD40 beta propeller (light blue and ...
Steven C. Almo (198342), Michael Brenowitz (15908), R. Holland Cheng (370710), Jeffrey B. Bonanno (382258), Janina Seznec (382259), Carola Wilczek (382257), Ulf Reimer (382265), Takashi Onikubo (382262), Man K. Chan (382264), Li Xing (35790), P. Rajesh Kumar (382263), Lester G. Carter (382261), Tsutomu Matsui (382260), Meng-Chiao Ho (198329), David Shechter (382266)   +14 more
core   +1 more source

Prognostic potential of PRMT5 and DSG2 proteins in pre-malignant cervical lesions

Precancerous cervical lesions are metaplastic alterations of epithelial cells of the cervix, eventually developing into cervical cancer. Despite primary and secondary prevention, the burden of cervical cancer remains high globally.
Veronika Mešťanová, Marian Adamkov, Bibiana Krajňáková, Desanka Výbohová, Sandra Hurta-Csizmár   +4 more
core   +1 more source

Subcloning, Expression, and Enzymatic Study of PRMT5

, 2010
Protein arginine methyltransferases (PRMTs)mediate the transfer of methyl groups to arginine residues in histone and non-histone proteins. PRMT5 is an important member of PRMTs which symmetrically dimethylates arginine 8 in histone H3 (H3R8) and arginine
Guo, Ran
core   +1 more source

Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice

Nature Communications
Protein arginine methyltransferase 5 (PRMT5) is a well-known epigenetic regulatory enzyme. However, the role of PRMT5-mediated arginine methylation in gene transcription related to cardiac fibrosis is unknown.
Yasufumi Katanasaka, Harumi Yabe, Noriyuki Murata, Minori Sobukawa, Yuga Sugiyama, Hikaru Sato, Hiroki Honda, Yoichi Sunagawa, Masafumi Funamoto, Satoshi Shimizu, Kana Shimizu, Toshihide Hamabe-Horiike, Philip Hawke, Maki Komiyama, Kiyoshi Mori, Koji Hasegawa, Tatsuya Morimoto   +16 more
doaj   +1 more source

PRMT5 and p44 co-exist in the cytoplasm.

, 2012
(A) Silencing PRMT5 expression decreased p44 protein levels in the cytoplasm. LNCaP cells were infected with NT-shRNA or PRMT5 shRNA and immunostained with anti-PRMT5 or -p44 antibody. The nucleus was counterstained with Sytox green (middle panels, green)
Zhongping Gu (144275), Chidan Wan (144282), Tao Liu (10785), Peng Lee (144280), Zhengxin Wang (144284), Yirong Li (144277)   +5 more
core   +1 more source

PRMT5 in mitochondria regulates mtDNA stability through TFAM arginine methylation

Nature Communications
Protein arginine methyltransferase 5 (PRMT5) catalyzes arginine methylation and regulates cellular functions such as proliferation, RNA splicing, and nuclear DNA damage response.
Sangheeta Bhattacharjee, Sayan Das, Banhi Chowdhury, Benu Brata Das   +3 more
doaj   +1 more source