Results 91 to 100 of about 8,519 (204)
PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis
Cell Communication and Signaling, 2019 Background The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation and cell cycle control.
Yi Qin +12 more
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PRMT5 controls the innate immune response [PDF]
Protein arginine methyltransferase 5 (PRMT5) is a symmetric di-methyltransferase frequently overexpressed in various cancers, including colorectal cancer.
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PRMT5 localized with p44 in the cytoplasm but not in the nucleus in prostate cancer cells.
, 2012 (A) PC3 and LNCaP cells were immunohistochemically stained with anti-PRMT5 and -p44 antibodies (panels a-g) or anti-PRMT5 plus -coilin antibodies (panel h).
Zhongping Gu (144275) +5 more
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PRMT5 in gene regulation and hematologic malignancies
Genes & Diseases, 2019 Arginine methylation is a common posttranslational modification that governs important cellular processes and impacts development, cell growth, proliferation, and differentiation. Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs), which are classified as type I and type II enzymes responsible for the formation of ...
Zhu, Fen, Rui, Lixin
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PLoS ONE, 2013 Protein arginine methyltransferase-5 (PRMT5) is a Type II arginine methyltransferase that regulates various cellular functions. We hypothesized that PRMT5 plays a role in regulating the growth of human melanoma cells.
Courtney Nicholas +12 more
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Structures of PRMT5 and the PRMT5:MEP50 complex.
, 2018 (A) An individual PRMT5 subunit from Protein Databank Entry 4GQB is represented as a ribbon diagram with dehydrosinefungin (white C atoms) and a histone H4 derived peptide (yellow C atoms) depicted as CPK spheres. The TIM barrel domain, Rossmann fold and
David E. Timm (3925361) +3 more
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ARD1의 PRMT5 아세틸화를 통한 PRMT5 기능과 세포 증식 조절 연구 [PDF]
, 2016 학위논문 (석사)-- 서울대학교 융합과학기술대학원 : 바이오제약학과, 2016. 8. 서영준.Arrest defective 1 (ARD1) was first identified in Saccharomyces cerevisiae and it has N-terminal acetyltransferase activity.
장재경
core
BiomoleculesPRMT5, a type II methyltransferase catalyzing symmetric dimethylation of arginine residues, has emerged as a promising therapeutic target in various cancers.
Yongshuai Jiang +6 more
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ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation
Summary: The stimulator of interferon genes (STING) is a vital protein for the activation of the type I interferon signaling pathway. Despite its critical role in immune response, the regulatory role of methylation in STING activation remains unclear ...
Chenglong Li +12 more
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The expression of PRMT5 is associated with postoperative chemotherapeutic outcome in colon cancer
BMC CancerBackground Postoperative chemotherapy is an essential treatment in locally advanced colon cancer, however, effective biomarkers for predicting patients who will benefit from this therapy are lacking.
Lu Lu +9 more
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