Results 81 to 90 of about 8,519 (204)

STRUCTURAL CHARACTERIZATION OF THE PRMT5-RIOK1-NUCLEOLIN COMPLEX

, 2021
Protein methylation is one of the most important protein post-translational modifications. Protein arginine methyltransferase 5 (PRMT5) catalyzes the mono- and symmetric dimethylation of arginine residues of a wide range of proteins that play critical ...
Wang, Hongpeng
core   +1 more source

PRMT5 Methylates and Stabilizes EphA2 via Inhibiting Its Ubiquitination and Degradation to Promote Nasopharyngeal Carcinoma Stem Cell Properties

MedComm
Both PRMT5 and EphA2 proteins are overexpressed and play a crucial role in multiple cancers, and have been used as targets to develop new anticancer drugs. However, the function and significance of the PRMT5–EphA2 interaction are unclear. Here, we report
Zheng‐Zheng Yu, Xue‐Li Mao, Shan‐Shan Lu, Ruo‐Huang Lu, Wei Zhu, Di Wu, Hong Yi, Wei Huang, Qi Wen, Guo‐Xiang Lin, Ting Zeng, Yun‐Xi Peng, Li Yuan, Ting Ran, Juan Feng, Jinwu Peng, Zhi‐Qiang Xiao   +16 more
doaj   +1 more source

PRMT5 Mediated HIF1α Signaling and Ras-Related Nuclear Protein as Promising Biomarker in Hepatocellular Carcinoma

Biology
Protein arginine N-methyltransferase 5 (PRMT5) has been identified as a potential therapeutic target for various cancer types. However, its role in regulating the hepatocellular carcinoma (HCC) transcriptome remains poorly understood.
Wafaa Abumustafa, Darko Castven, Fatemeh Saheb Sharif-Askari, Batoul Abi Zamer, Mawieh Hamad, Jens-Uwe Marquardt, Jibran Sualeh Muhammad   +6 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, Volume 7, Issue 3, Page 109-124, September 2026.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome

, 2014
International audienceSymmetrical dimethylation on arginine-3 of histone H4 (H4R3me2s) has been reported to occur at several repressed genes, but its specific regulation and genomic distribution remained unclear.
Pontis, Julien, Ait-Si-Ali, S., Fabbrizio, Eric, Hirasawa, Ryutaro, Kadam, Shilpa, Kota, Satya, Kota, Satya,, Kota, Satya, K., Kota, Satya K., Girardot, Michael, Ait-Si-Ali, Slimane, Kacem, Salim, Kadam, S., Feil, Robert, Fritsch, Lauriane, Lohmann, Felix, Sardet, Claude, Lohmann, F., Pontis, J., Filipponi, Doria, Fritsch, L.   +20 more
core   +1 more source

PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C‐Myc Feedback Loop

MedComm
The oncogenic role and underlying mechanism of PRMT5 in pancreatic ductal adenocarcinoma (PAAD) remained to be elucidated. In this study, we aimed to investigate the oncogenic role, underlying molecular mechanisms, and potential therapeutic value of ...
Fan Yang, Ping Song, Zhaofeng Xiao, Renyi Su, Xin Fang, Yichao Wu, Xiao Xu, Kai Wang   +7 more
doaj   +1 more source

PRMT5 promotes cell proliferation by inhibiting BTG2 expression via the ERK signaling pathway in hepatocellular carcinoma

Cancer Medicine, 2018
Increasing evidence suggests that PRMT5, a protein arginine methyltransferase, has roles in cell growth regulation and cancer development. However, the role of PRMT5 in hepatocellular carcinoma (HCC) progression remains unclear.
Hai Jiang, Yue Zhu, Zhenyu Zhou, Junyang Xu, Shaowen Jin, Kang Xu, Heyun Zhang, Qing Sun, Jie Wang, Junyao Xu   +9 more
doaj   +1 more source

NF-κB/mTOR/MYC Axis Drives PRMT5 Protein Induction After T Cell Activation via Transcriptional and Non-transcriptional Mechanisms

Frontiers in Immunology, 2019
Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) mediated by CD4+ T cells and modeled via experimental autoimmune encephalomyelitis (EAE).
Lindsay M. Webb, Lindsay M. Webb, Janiret Narvaez Miranda, Stephanie A. Amici, Shouvonik Sengupta, Shouvonik Sengupta, Gregory Nagy, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano   +10 more
doaj   +1 more source

Methods for PRMT5 cellular assay

, 2020
Methods for cellular PRMT5 assay posted on openlabnotebook ...
Magdalena Szewczyk
core   +1 more source

LKB1 regulates PRMT5 activity in breast cancer

, 2019
International audienceProtein arginine methyltransferase 5 (PRMT5) is the main enzyme responsible for the symmetrical dimethylation of arginine residues on target proteins in both the cytoplasm and the nucleus.
Poulard, Coralie, Lattouf, Hanine, Hanine Lattouf, Laura Corbo, Kassem, Loay, Nader Hussein, Mona Diab‐Assaf, Diab-Assaf, Mona, Loay Kassem, Jacquemetton, Julien, Olivier Trédan, Trédan, Olivier, Julien Jacquemetton, Choucair, Ali, Corbo, Laura, Hussein, Nader, Coralie Poulard, Ali Choucair, Le Romancer, Muriel, Treilleux, Isabelle, Muriel Le Romancer, Isabelle Treilleux   +21 more
core   +1 more source