Results 191 to 200 of about 1,051,322 (230)

Impaired neonatal survival of pro-opiomelanocortin null mutants

Molecular and Cellular Endocrinology, 2011
Intercrosses of heterozygous pro-opiomelanocortin (POMC) mice result in homozygous null progeny at lower frequencies than expected. Genotyping offspring at pre-, peri-, and postnatal stages revealed that over half of homozygous null mutants die in the early postnatal stages.
Katarzyna, Saedler, Ute, Hochgeschwender
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The pro-opiomelanocortin gene of the zebrafish (Danio rerio)

Biochemical and Biophysical Research Communications, 2003
The cDNA and the gene for pro-opiomelanocortin (POMC) in the zebrafish (Danio rerio) were isolated and analyzed. The gene consists of three exons and two short introns and has a similar overall structural organization as in Homo sapiens. Intron 1 (339 bp) divides the 5(') untranslated region from the coding region while intron 2 (1522 bp) is located ...
Immo A, Hansen, Thuy T, To, Sebastian, Wortmann, Thorsten, Burmester, Christoph, Winkler, Susanne R, Meyer, Cordula, Neuner, Martin, Fassnacht, Bruno, Allolio   +8 more
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Delayed Pro‐Opiomelanocortin Activation after Ethanol Intake in Man

Alcoholism: Clinical and Experimental Research, 1994
To elucidate the effect of ethanol on the secretion of ACTH and β‐endorphin (BE) as the representatives of the pro‐opiomelanocortin (POMC) system, as well as cortisol as the hypophyseally regulated peripheral hormone, we measured concentrations of serum ethanol and plasma ACTH, BE, and cortisol at 1‐ to 4‐hr intervals for 12 hr after administration of ...
A C, Ekman, O, Vakkuri, O, Vuolteenaho, J, Leppäluoto   +3 more
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Pro-opiomelanocortin (POMC) Deficiency and Peripheral Melanocortins in Obesity

Nutrition Reviews, 2009
Melanocortin peptides, derived from pro-opiomelanocortin (POMC), appear to play a significant role in appetite and body weight regulation. Expression of the Pomc gene in the central nervous system results in the production of melanocortin peptides, which bind to the melanocortin-4 receptor (MC4-R) and inhibit food intake.
M B, Zemel, H, Shi
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Posttranslational processing of opioid pro-opiomelanocortin products in piglets

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1989
We have measured levels of beta-lipotropin, beta-endorphin, and N-acetyl-beta-endorphin in the plasma, cerebrospinal fluid (CSF), and caudal medullary brain containing the respiratory-related portion of the nucleus tractus solitarius (NTS) of 2.5 +/- 1.0- (SD) and 38.2 +/- 3.7-day-old naive uninstrumented piglets.
I R, Moss, J G, Inman, C A, Slaughter
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Chemistry and biosynthesis of pro-opiomelanocortin

Molecular and Cellular Biochemistry, 1981
Studies of lipotropins, melanotropins and endorphins on one hand, and of adrenocorticotropin on the other, has given rise to the concept of a multipotent precursor molecule recently renamed proopiomelanocortin. The preferential sites of cleavage of the precursor to produce its biologically active components are made of pairs of basic amino acid ...
M, Chrétien, N G, Seidah
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Effects of pro-opiomelanocortin peptides on adrenocortical steroidogenesis

The Journal of Steroid Biochemistry and Molecular Biology, 1993
Whilst studying the effects of pro-opiomelanocortin (POMC) peptides on adrenocortical steroidogenesis we showed that alpha-melanocyte-stimulating hormone (alpha-MSH) has a specific glomerulotropic effect and potentiates both the mineralocorticotropic and glucocorticotropic effects of ACTH.
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Discovery of pro-opiomelanocortin-a cellular polyprotein

Trends in Biochemical Sciences, 1981
Abstract Pro-opiomelanocortin (POMC) contains the sequences of ACTH, -endorphin and melanocyte stimulating hormones. POMC is present in both the anterior and intermediate lobes of the pituitary but it is processed to different hormones in each lobe. Release of these hormones is also regulated differently in the two lobes.
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Expression of pro-opiomelanocortin gene in human ovarian tissue.

Human reproduction (Oxford, England), 1995
The high concentration of pro-opiomelanocortin (POMC)-derived peptides in human follicular fluid, which is several times higher than in plasma, suggested a local expression of the POMC gene. This has previously been observed in the animal ovaries. Peripheral POMC-like mRNAs are not translated in POMC-derived peptides but recent evidence supports the ...
Gallinelli A, Garuti G, Matteo ML, GENAZZANI, ANDREA, Facchinetti F.   +4 more
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Natriuretic and hypertensinogenic pro-opiomelanocortin derived peptides

Regulatory Peptides, 1985
K A, Gruber, M F, Callahan, R F, Kirby, A K, Johnson, J R, Lymangrover   +4 more
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