Results 181 to 190 of about 1,051,322 (230)

Pro-Opiomelanocortin and adrenal function

Endocrine Research, 1996
Pro-opiomelanocortin (POMC) is a polyhormone precursor produced predominantly in the pars distalis and pars intermedia of the pituitary gland where it undergoes tissue specific processing to produce a whole array of peptides. We have shown previously that peptides derived from the N-terminal region of POMC are involved in adrenal growth in rats.
A B, Bicknell, D, Savva, P J, Lowry
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Pro-opiomelanocortin peptides and the adrenal gland

Molecular and Cellular Endocrinology, 2007
The adrenal gland regulates a number of essential biological functions through production of steroids and catecholamines. Pro-opiomelanocortin (POMC)-derived peptides have been implicated in all aspects of generating, maintaining, and functioning of the adrenal glands.
Jason, Karpac, Andras, Kern, Ute, Hochgeschwender   +2 more
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Glucocorticoid repression of pro-opiomelanocortin gene transcription

Journal of Steroid Biochemistry, 1989
Transcription of the pro-opiomelanocortin (POMC) gene is repressed by glucocorticoids in the anterior pituitary gland. We have defined an element within the POMC promoter which is responsible for this regulatory feedback. This element, the "negative glucocorticoid response element" (nGRE), was localized in the proximal region of the POMC promoter and ...
J, Drouin, Y L, Sun, M, Nemer
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Pro-opiomelanocortin gene expression in human phaeochromocytomas

Journal of Molecular Endocrinology, 1989
ABSTRACT Phaeochromocytoma is an occasional cause of the ectopic ACTH syndrome. The mechanisms of proopiomelanocortin (POMC) gene expression were analysed in 11 human tumours not associated with Cushing's syndrome, by detecting and characterizing the POMC mRNA. A DNA probe corresponding to most of the protein-coding region of the third exon was used in
Y, de Keyzer, M F, Rousseau-Merck, J P, Luton, F, Girard, A, Kahn, X, Bertagna   +5 more
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Pro-opiomelanocortin Peptides in Reproductive Physiology

Hospital Practice, 1988
Locally synthesized POMC-derived peptides seem to act as paracrine and autocrine regulators of testicular growth and function; some are stimulatory, others inhibitory. They add up to a potent short-loop effector system, with a significant role in both the up- and downregulation of the mechanisms subserved by the long-loop hypothalamic-pituitary-adrenal-
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Sequence of the cDNA encoding porcine pro-opiomelanocortin

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1986
Messenger RNA was extracted from porcine pituitary pars intermedia and cloned as cDNA by standard methods. The nucleotide sequence encoding porcine pro-opiomelanocortin was established from analysis of two separate cDNA segments having an overlap of 420 bases. The amino acid sequence for the porcine pro-opiomelanocortin protein, which was inferred from
F J, Gossard, A C, Chang, S N, Cohen
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Pro-opiomelanocortin peptides in the human fetal pituitary

Regulatory Peptides, 1983
Abstract Levels of immunoreactive pro-opiomelanocortin (POMC) peptides (N- and C-terminal ACTH, N- and C-terminal LPH and α-MSH) have been measured in pituitary extracts from human fetuses of 12–22 weeks gestation. The levels of ACTH were 30–200 times higher than α-MSH in all fetuses studied. Sephadex G-75 and G-25 chromatography of 8 extracts showed
J, Ackland, S, Ratter, G, Bourne, L H, Rees   +3 more
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Effect of Androgens on Hypothalamic Pro-Opiomelanocortin

Neuroendocrinology, 1988
Testosterone and estradiol have been shown to affect the hypothalamic content of several pro-opiomelanocortin (POMC)-derived peptides in castrated male and female rats, respectively. It was unclear, however, whether the effects of testosterone on hypothalamic POMC were due to conversion by aromatization to estradiol or whether there were independent ...
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Pro-Opiomelanocortin-Containing Neurons in Rat Median Eminence

Neuroendocrinology, 1992
A significant number of pro-opiomelanocortin (POMC)-containing cells were detected in the rat median eminence (ME) by immunocytochemistry using an antibody raised against a synthetic peptide corresponding to the cleavage site between adrenocorticotropin and beta-lipotropin moieties.
K, Ishikawa, K, Katakai, S, Tanaka, S, Haga, H, Mochida, K, Itoh   +5 more
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[Pro-opiomelanocortin neuronal systems].

Revue neurologique, 1987
Proopiomelanocortin (POMC) is a glycoprotein which serves as a multihormonal precursor for corticotropin (ACTH), lipotropins (beta and gamma-LPH), melanotropins (alpha, beta- and gamma-MSH) and endorphins (alpha-, beta- and gamma-endorphins). This precursor protein is primarily synthesized in corticotrophs of the anterior lobe and in melanotrophs of ...
D, Tranchand-Bunel, C, Delbende, J, Guy, S, Jegou, B J, Jenks, E, Mocaër, G, Pelletier, H, Vaudry   +7 more
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