Results 161 to 170 of about 1,067,103 (202)

Glucocorticoid repression of pro-opiomelanocortin gene transcription

Journal of Steroid Biochemistry, 1989
Transcription of the pro-opiomelanocortin (POMC) gene is repressed by glucocorticoids in the anterior pituitary gland. We have defined an element within the POMC promoter which is responsible for this regulatory feedback. This element, the "negative glucocorticoid response element" (nGRE), was localized in the proximal region of the POMC promoter and ...
J, Drouin, Y L, Sun, M, Nemer
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Pro-opiomelanocortin gene expression in human phaeochromocytomas

Journal of Molecular Endocrinology, 1989
ABSTRACT Phaeochromocytoma is an occasional cause of the ectopic ACTH syndrome. The mechanisms of proopiomelanocortin (POMC) gene expression were analysed in 11 human tumours not associated with Cushing's syndrome, by detecting and characterizing the POMC mRNA. A DNA probe corresponding to most of the protein-coding region of the third exon was used in
Y, de Keyzer, M F, Rousseau-Merck, J P, Luton, F, Girard, A, Kahn, X, Bertagna   +5 more
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Chemistry and biosynthesis of pro-opiomelanocortin

Molecular and Cellular Biochemistry, 1981
Studies of lipotropins, melanotropins and endorphins on one hand, and of adrenocorticotropin on the other, has given rise to the concept of a multipotent precursor molecule recently renamed proopiomelanocortin. The preferential sites of cleavage of the precursor to produce its biologically active components are made of pairs of basic amino acid ...
M, Chrétien, N G, Seidah
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Effects of pro-opiomelanocortin peptides on adrenocortical steroidogenesis

The Journal of Steroid Biochemistry and Molecular Biology, 1993
Whilst studying the effects of pro-opiomelanocortin (POMC) peptides on adrenocortical steroidogenesis we showed that alpha-melanocyte-stimulating hormone (alpha-MSH) has a specific glomerulotropic effect and potentiates both the mineralocorticotropic and glucocorticotropic effects of ACTH.
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Structure and bioactivity of the amino-terminal fragment of pro-opiomelanocortin

Journal of Steroid Biochemistry, 1986
The primary sequence of the amino-terminal or 16 K fragment (16 K) of pro-opiomelanocortin (POMC) is highly conserved throughout the mammals. This suggests an important biological role for this peptide. We have performed studies to determine the structure, biosynthetic origin and bioactivity of this pituitary peptide.
M A, Seger, H P, Bennett
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Regulation of pro-opiomelanocortin biosynthesis and processing by transplantation immunity

Nature, 1989
It is more than thirty years since Billingham and Medawar showed that adrenocorticotrophic hormone (ACTH) and cortisol can prolong the survival of skin allografts. It has since become clear that glucocorticoid hormones are critically involved in the regulation of immunity.
S, Zakarian, M S, Eleazar, W K, Silvers
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[Pro-opiomelanocortin neuronal systems].

Revue neurologique, 1987
Proopiomelanocortin (POMC) is a glycoprotein which serves as a multihormonal precursor for corticotropin (ACTH), lipotropins (beta and gamma-LPH), melanotropins (alpha, beta- and gamma-MSH) and endorphins (alpha-, beta- and gamma-endorphins). This precursor protein is primarily synthesized in corticotrophs of the anterior lobe and in melanotrophs of ...
D, Tranchand-Bunel, C, Delbende, J, Guy, S, Jegou, B J, Jenks, E, Mocaër, G, Pelletier, H, Vaudry   +7 more
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Pro-Opiomelanocortin-Containing Neurons in Rat Median Eminence

Neuroendocrinology, 2008
A significant number of pro-opiomelanocortin (POMC)-containing cells were detected in the rat median eminence (ME) by immunocytochemistry using an antibody raised against a synthetic peptide corresponding to the cleavage site between adrenocorticotropin and β-lipotropin moieties.
K, Ishikawa, K, Katakai, S, Tanaka, S, Haga, H, Mochida, K, Itoh   +5 more
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Posttranslational processing of opioid pro-opiomelanocortin products in piglets

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1989
We have measured levels of beta-lipotropin, beta-endorphin, and N-acetyl-beta-endorphin in the plasma, cerebrospinal fluid (CSF), and caudal medullary brain containing the respiratory-related portion of the nucleus tractus solitarius (NTS) of 2.5 +/- 1.0- (SD) and 38.2 +/- 3.7-day-old naive uninstrumented piglets.
I R, Moss, J G, Inman, C A, Slaughter
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Impaired neonatal survival of pro-opiomelanocortin null mutants

Molecular and Cellular Endocrinology, 2011
Intercrosses of heterozygous pro-opiomelanocortin (POMC) mice result in homozygous null progeny at lower frequencies than expected. Genotyping offspring at pre-, peri-, and postnatal stages revealed that over half of homozygous null mutants die in the early postnatal stages.
Katarzyna, Saedler, Ute, Hochgeschwender
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