Results 161 to 170 of about 1,457,386 (196)

Structure and bioactivity of the amino-terminal fragment of pro-opiomelanocortin

Journal of Steroid Biochemistry, 1986
The primary sequence of the amino-terminal or 16 K fragment (16 K) of pro-opiomelanocortin (POMC) is highly conserved throughout the mammals. This suggests an important biological role for this peptide. We have performed studies to determine the structure, biosynthetic origin and bioactivity of this pituitary peptide.
M A, Seger, H P, Bennett
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Regulation of pro-opiomelanocortin biosynthesis and processing by transplantation immunity

Nature, 1989
It is more than thirty years since Billingham and Medawar showed that adrenocorticotrophic hormone (ACTH) and cortisol can prolong the survival of skin allografts. It has since become clear that glucocorticoid hormones are critically involved in the regulation of immunity.
S, Zakarian, M S, Eleazar, W K, Silvers
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Pro-Opiomelanocortin-Containing Neurons in Rat Median Eminence

Neuroendocrinology, 2008
A significant number of pro-opiomelanocortin (POMC)-containing cells were detected in the rat median eminence (ME) by immunocytochemistry using an antibody raised against a synthetic peptide corresponding to the cleavage site between adrenocorticotropin and β-lipotropin moieties.
K, Ishikawa, K, Katakai, S, Tanaka, S, Haga, H, Mochida, K, Itoh   +5 more
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Posttranslational processing of opioid pro-opiomelanocortin products in piglets

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1989
We have measured levels of beta-lipotropin, beta-endorphin, and N-acetyl-beta-endorphin in the plasma, cerebrospinal fluid (CSF), and caudal medullary brain containing the respiratory-related portion of the nucleus tractus solitarius (NTS) of 2.5 +/- 1.0- (SD) and 38.2 +/- 3.7-day-old naive uninstrumented piglets.
I R, Moss, J G, Inman, C A, Slaughter
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Dynorphin in pro-opiomelanocortin neurons of the hypothalamic arcuate nucleus

Neuroscience, 2008
Considerable evidence suggests that dynorphin participates in the regulation of energy balance. In this study, we have used immunohistochemistry to investigate in detail the cellular localization of pro-dynorphin (DYN) immunoreactive cell bodies in the mediobasal hypothalamus with special reference to neurons producing orexigenic or anorexigenic ...
N, Maolood, B, Meister
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Discovery of pro-opiomelanocortin-a cellular polyprotein

Trends in Biochemical Sciences, 1981
Abstract Pro-opiomelanocortin (POMC) contains the sequences of ACTH, -endorphin and melanocyte stimulating hormones. POMC is present in both the anterior and intermediate lobes of the pituitary but it is processed to different hormones in each lobe. Release of these hormones is also regulated differently in the two lobes.
openaire   +1 more source

Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

Biochemical Journal, 2010
Melanocortin peptides, derived from POMC (pro-opiomelanocortin) are produced in the ARH (arcuate nucleus of the hypothalamus) neurons and the neurons in the commissural NTS (nucleus of the solitary tract) of the brainstem, in anterior and intermediate lobes of the pituitary, skin and a wide range of peripheral tissues, including reproductive organs.
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Intracellular trafficking and processing of pro-opiomelanocortin

Cell Biophysics, 1991
Y P, Loh, K I, Andreasson, N P, Birch
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Pro-opiomelanocortin Deficiency

2009
Heiko Krude, Annette Grüters
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Autism and the pro-opiomelanocortin system

European Neuropsychopharmacology, 1994
J.K. Buitelaar, H. van Engeland, C. Kemner, M.N. Verbaten, S.H.N. Swinkels   +4 more
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