Results 151 to 160 of about 1,457,386 (196)
Neuroendocrinology, 1988 The effect of frontal deafferentation of the medial basal hypothalamus on pro-opiomelanocortin (POMC) gene expression was studied in the intermediate lobe (IL) and anterior lobe (AL) of the pituitary gland in the absence and presence of corticosterone ...
J Z Kiss +2 more
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The Pro-Opiomelanocortin Gene of the Zebrafish (Danio Rerio)
Biochemical and Biophysical Research Communications, 2003The cDNA and the gene for pro-opiomelanocortin (POMC) in the zebrafish (Danio rerio) were isolated and analyzed. The gene consists of three exons and two short introns and has a similar overall structural organization as in Homo sapiens. Intron 1 (339 bp) divides the 5(') untranslated region from the coding region while intron 2 (1522 bp) is located ...
Martin Fassnacht +2 more
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Pro-opiomelanocortin Peptides in Reproductive Physiology
Hospital Practice, 1988Locally synthesized POMC-derived peptides seem to act as paracrine and autocrine regulators of testicular growth and function; some are stimulatory, others inhibitory. They add up to a potent short-loop effector system, with a significant role in both the up- and downregulation of the mechanisms subserved by the long-loop hypothalamic-pituitary-adrenal-
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Effect of Androgens on Hypothalamic Pro-Opiomelanocortin
Neuroendocrinology, 2008Testosterone and estradiol have been shown to affect the hypothalamic content of several pro-opiomelanocortin (POMC)-derived peptides in castrated male and female rats, respectively. It was unclear, however, whether the effects of testosterone on hypothalamic POMC were due to conversion by aromatization to estradiol or whether there were independent ...
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Pro-opiomelanocortin peptides in the human fetal pituitary
Regulatory Peptides, 1983Abstract Levels of immunoreactive pro-opiomelanocortin (POMC) peptides (N- and C-terminal ACTH, N- and C-terminal LPH and α-MSH) have been measured in pituitary extracts from human fetuses of 12–22 weeks gestation. The levels of ACTH were 30–200 times higher than α-MSH in all fetuses studied. Sephadex G-75 and G-25 chromatography of 8 extracts showed
J, Ackland +3 more
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Pro-opiomelanocortin gene expression in human phaeochromocytomas
Journal of Molecular Endocrinology, 1989ABSTRACT Phaeochromocytoma is an occasional cause of the ectopic ACTH syndrome. The mechanisms of proopiomelanocortin (POMC) gene expression were analysed in 11 human tumours not associated with Cushing's syndrome, by detecting and characterizing the POMC mRNA.
Y, de Keyzer +5 more
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Glucocorticoid repression of pro-opiomelanocortin gene transcription
Journal of Steroid Biochemistry, 1989Transcription of the pro-opiomelanocortin (POMC) gene is repressed by glucocorticoids in the anterior pituitary gland. We have defined an element within the POMC promoter which is responsible for this regulatory feedback. This element, the "negative glucocorticoid response element" (nGRE), was localized in the proximal region of the POMC promoter and ...
J, Drouin, Y L, Sun, M, Nemer
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Chemistry and biosynthesis of pro-opiomelanocortin
Molecular and Cellular Biochemistry, 1981Studies of lipotropins, melanotropins and endorphins on one hand, and of adrenocorticotropin on the other, has given rise to the concept of a multipotent precursor molecule recently renamed proopiomelanocortin. The preferential sites of cleavage of the precursor to produce its biologically active components are made of pairs of basic amino acid ...
M, Chrétien, N G, Seidah
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Effects of pro-opiomelanocortin peptides on adrenocortical steroidogenesis
The Journal of Steroid Biochemistry and Molecular Biology, 1993Whilst studying the effects of pro-opiomelanocortin (POMC) peptides on adrenocortical steroidogenesis we showed that alpha-melanocyte-stimulating hormone (alpha-MSH) has a specific glomerulotropic effect and potentiates both the mineralocorticotropic and glucocorticotropic effects of ACTH.
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[Pro-opiomelanocortin neuronal systems].
Revue neurologique, 1987Proopiomelanocortin (POMC) is a glycoprotein which serves as a multihormonal precursor for corticotropin (ACTH), lipotropins (beta and gamma-LPH), melanotropins (alpha, beta- and gamma-MSH) and endorphins (alpha-, beta- and gamma-endorphins). This precursor protein is primarily synthesized in corticotrophs of the anterior lobe and in melanotrophs of ...
D, Tranchand-Bunel +7 more
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