Results 151 to 160 of about 1,067,103 (202)
Expression of pro-opiomelanocortin gene in human ovarian tissue.
Human reproduction (Oxford, England), 1995 The high concentration of pro-opiomelanocortin (POMC)-derived peptides in human follicular fluid, which is several times higher than in plasma, suggested a local expression of the POMC gene. This has previously been observed in the animal ovaries. Peripheral POMC-like mRNAs are not translated in POMC-derived peptides but recent evidence supports the ...
Gallinelli A +4 more
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Pro-Opiomelanocortin and Behavioral Homeostasis
Hospital Practice, 1988The large POMC molecule is hydrolyzed into a wide array of bioactive fragments. Some—such as ACTH, β-lipotropin, and β-endorphin—are well understood; others, less so. In concert with the glucocorticoids, these neuropeptides appear to be critical mediators of CNS homeostasis and facilitators of adaptive behavior. They work both systemically and locally,
D, de Wied, R, de Kloet
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Pro-Opiomelanocortin and adrenal function
Endocrine Research, 1996Pro-opiomelanocortin (POMC) is a polyhormone precursor produced predominantly in the pars distalis and pars intermedia of the pituitary gland where it undergoes tissue specific processing to produce a whole array of peptides. We have shown previously that peptides derived from the N-terminal region of POMC are involved in adrenal growth in rats.
A B, Bicknell, D, Savva, P J, Lowry
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Plasminogen regulates pro‐opiomelanocortin processing
Journal of Thrombosis and Haemostasis, 2004Plasminogen-deficient mice exhibit behavioral differences in response to stress, including a markedly reduced acoustic startle reflex response compared with wild-type (WT) littermates. The acoustic startle reflex activates the hypothalamic-pituitary axis and is modulated by these hormones.The purpose of this study was to investigate whether plasminogen
N, Wang +3 more
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FEBS Letters, 1991 The amino terminus of bovine pro-opiomelanocortin (N-POMC1–77) is partially processed in the intermediate lobe of the pituitary to N-POMC1–49 and lys-γ3 -melanotropin.
Nigel P Birch +2 more
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Rat Pro-Opiomelanocortin Contains Sulfate
Science, 1982Intermediate lobes isolated from rat pituitary glands incorporated [ 35 S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller ...
H, Hoshina, G, Hortin, I, Boime
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Pro-opiomelanocortin peptides and the adrenal gland
Molecular and Cellular Endocrinology, 2007The adrenal gland regulates a number of essential biological functions through production of steroids and catecholamines. Pro-opiomelanocortin (POMC)-derived peptides have been implicated in all aspects of generating, maintaining, and functioning of the adrenal glands.
Jason, Karpac +2 more
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Pro-opiomelanocortin Peptides in Reproductive Physiology
Hospital Practice, 1988Locally synthesized POMC-derived peptides seem to act as paracrine and autocrine regulators of testicular growth and function; some are stimulatory, others inhibitory. They add up to a potent short-loop effector system, with a significant role in both the up- and downregulation of the mechanisms subserved by the long-loop hypothalamic-pituitary-adrenal-
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Effect of Androgens on Hypothalamic Pro-Opiomelanocortin
Neuroendocrinology, 2008Testosterone and estradiol have been shown to affect the hypothalamic content of several pro-opiomelanocortin (POMC)-derived peptides in castrated male and female rats, respectively. It was unclear, however, whether the effects of testosterone on hypothalamic POMC were due to conversion by aromatization to estradiol or whether there were independent ...
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Pro-opiomelanocortin peptides in the human fetal pituitary
Regulatory Peptides, 1983Abstract Levels of immunoreactive pro-opiomelanocortin (POMC) peptides (N- and C-terminal ACTH, N- and C-terminal LPH and α-MSH) have been measured in pituitary extracts from human fetuses of 12–22 weeks gestation. The levels of ACTH were 30–200 times higher than α-MSH in all fetuses studied. Sephadex G-75 and G-25 chromatography of 8 extracts showed
J, Ackland +3 more
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