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Structure of the Rat Pro-Opiomelanocortin (POMC) Gene [PDF]

FEBS Letters, 1985
The gene encoding pro‐opiomelanocortin (POMC) presents unique regulatory features. In particular, glucocorticoids inhibit transcription of the POMC gene in the anterior pituitary, but not in the intermediate pituitary. In order to study the mechanism leading to transcriptional inhibition of POMC by glucocorticoid and the interaction of the ...
Lucie Jeannotte, Jacques Drouin, Mona Nemer   +2 more
exaly   +3 more sources

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Rat Pro-Opiomelanocortin Contains Sulfate

Science, 1982
Intermediate lobes isolated from rat pituitary glands incorporated [ 35 S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller ...
G Hortin
exaly   +3 more sources

Sequence of the cDNA Encoding Porcine Pro-Opiomelanocortin

Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 1986
Messenger RNA was extracted from porcine pituitary pars intermedia and cloned as cDNA by standard methods. The nucleotide sequence encoding porcine pro-opiomelanocortin was established from analysis of two separate cDNA segments having an overlap of 420 bases. The amino acid sequence for the porcine pro-opiomelanocortin protein, which was inferred from
Stanley Norman Cohen, Annie C Y Chang, A C Chang   +2 more
exaly   +3 more sources

Ectopic pro-opiomelanocortin syndrome

Endocrinology and Metabolism Clinics of North America, 2002
Ectopic POMC syndrome remains one of the most challenging differential diagnoses in endocrinology. Recent progress in the understanding of the tissue specific regulation of POMC gene expression and new insights into the processing of the POMC peptide in nonpituitary tissues has helped elucidate some of the molecular events leading to ectopic expression
Beuschlein, Felix, Hammer, Gary D.
openaire   +3 more sources

Pro-Opiomelanocortin and adrenal function

Endocrine Research, 1996
Pro-opiomelanocortin (POMC) is a polyhormone precursor produced predominantly in the pars distalis and pars intermedia of the pituitary gland where it undergoes tissue specific processing to produce a whole array of peptides. We have shown previously that peptides derived from the N-terminal region of POMC are involved in adrenal growth in rats.
A B, Bicknell, D, Savva, P J, Lowry
openaire   +2 more sources

Pro-Opiomelanocortin and Behavioral Homeostasis

Hospital Practice, 1988
The large POMC molecule is hydrolyzed into a wide array of bioactive fragments. Some—such as ACTH, β-lipotropin, and β-endorphin—are well understood; others, less so. In concert with the glucocorticoids, these neuropeptides appear to be critical mediators of CNS homeostasis and facilitators of adaptive behavior. They work both systemically and locally,
D, de Wied, R, de Kloet
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Plasminogen regulates pro‐opiomelanocortin processing

Journal of Thrombosis and Haemostasis, 2004
Plasminogen-deficient mice exhibit behavioral differences in response to stress, including a markedly reduced acoustic startle reflex response compared with wild-type (WT) littermates. The acoustic startle reflex activates the hypothalamic-pituitary axis and is modulated by these hormones.The purpose of this study was to investigate whether plasminogen
N, Wang, L, Zhang, L, Miles, J, Hoover-Plow   +3 more
openaire   +2 more sources

Pro-opiomelanocortin peptides and the adrenal gland

Molecular and Cellular Endocrinology, 2007
The adrenal gland regulates a number of essential biological functions through production of steroids and catecholamines. Pro-opiomelanocortin (POMC)-derived peptides have been implicated in all aspects of generating, maintaining, and functioning of the adrenal glands.
Jason, Karpac, Andras, Kern, Ute, Hochgeschwender   +2 more
openaire   +2 more sources