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Polymorphism of Melanocortin Receptor Genes-Association with Inflammatory Traits and Diseases. [PDF]

open access: yesDiseases
Bardhan M   +12 more
europepmc   +1 more source
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Rat pro-opiomelanocortin contains sulfate

Science, 1982
Intermediate lobes isolated from rat pituitary glands incorporated [ 35 S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller ...
H, Hoshina, G, Hortin, I, Boime
exaly   +3 more sources

Ectopic pro-opiomelanocortin syndrome

Endocrinology and Metabolism Clinics of North America, 2002
Ectopic POMC syndrome remains one of the most challenging differential diagnoses in endocrinology. Recent progress in the understanding of the tissue specific regulation of POMC gene expression and new insights into the processing of the POMC peptide in nonpituitary tissues has helped elucidate some of the molecular events leading to ectopic expression
Beuschlein, Felix, Hammer, Gary D.
openaire   +3 more sources

Plasminogen regulates pro‐opiomelanocortin processing

Journal of Thrombosis and Haemostasis, 2004
Plasminogen-deficient mice exhibit behavioral differences in response to stress, including a markedly reduced acoustic startle reflex response compared with wild-type (WT) littermates. The acoustic startle reflex activates the hypothalamic-pituitary axis and is modulated by these hormones.The purpose of this study was to investigate whether plasminogen
N, Wang   +3 more
openaire   +2 more sources

Pro-Opiomelanocortin and Behavioral Homeostasis

Hospital Practice, 1988
The large POMC molecule is hydrolyzed into a wide array of bioactive fragments. Some—such as ACTH, β-lipotropin, and β-endorphin—are well understood; others, less so. In concert with the glucocorticoids, these neuropeptides appear to be critical mediators of CNS homeostasis and facilitators of adaptive behavior. They work both systemically and locally,
D, de Wied, R, de Kloet
openaire   +2 more sources

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