Results 271 to 280 of about 142,423 (312)

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

ATP6ap2/(Pro)renin receptor

Shinzo, 2011
openaire   +1 more source

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The (pro)renin receptor in health and disease

Nature Reviews Nephrology, 2019
The (pro)renin receptor ((P)RR) was first identified as a single-transmembrane receptor in human kidneys and initially attracted attention owing to its potential role as a regulator of the tissue renin-angiotensin system (RAS). Subsequent studies found that the (P)RR is widely distributed in organs throughout the body, including the kidneys, heart ...
A. Ichihara, M. Yatabe
semanticscholar   +3 more sources

The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma

Reproduction, 2021
Abstract This study aimed to determine if the (pro)renin receptor (ATP6AP2) changes the cellular profile of choriocarcinomas from cytotrophoblast cells to terminally syncytialised cells and ascertain whether this impacts the invasive potential of choriocarcinoma cells.
Morosin, Saije K., Delforce, Sarah J., Kahl, Richard G. S., de Meaultsart, Celine Corbisier, Lumbers, Eugenie R., Pringle, Kirsty G.   +5 more
openaire   +2 more sources

The (pro)renin receptors

Journal of Molecular Medicine, 2008
Two (pro)renin receptors have been characterized so far, the mannose-6-phosphate receptor (M6P-R) and a specific receptor called (P)RR for (pro)renin receptor. Each receptor controls a different aspect of renin and prorenin metabolism. The M6P-R is a clearance receptor, whereas (P)RR mediates their cellular effects by activating intracellular signaling
Geneviève, Nguyen, Aurélie, Contrepas
openaire   +2 more sources

PLZF and the (pro)renin receptor

Journal of Molecular Medicine, 2008
For many years, angiotensin II with its respective receptors was considered to be the only effector molecule within the renin-angiotensin system. Nevertheless, several studies indicated that renin (the enzyme catalyzing the generation of angiotensin I) and its enzymatically inactive precursor prorenin may have an angiotensin-II-independent (patho ...
Jan H, Schefe, Thomas, Unger, Heiko, Funke-Kaiser   +2 more
openaire   +2 more sources

The (Pro)Renin Receptor and the Kidney

Seminars in Nephrology, 2007
Prorenin binding to the (pro)renin receptor not only causes a nonproteolytic activation of prorenin leading to the activation of the renin-angiotensin system (RAS), but also stimulates the receptor's own intracellular signaling pathways independent of the RAS.
Atsuhiro, Ichihara, Yuki, Kaneshiro, Tomoko, Takemitsu, Mariyo, Sakoda, Hiroshi, Itoh   +4 more
openaire   +2 more sources

Downregulation of the (pro)renin receptor alleviates ferroptosis-associated cardiac pathological changes via the NCOA 4-mediated ferritinophagy pathway in diabetic cardiomyopathy.

International Immunopharmacology
Ferroptosis, characterized by the accumulation of reactive oxygen species and lipid peroxidation, is involved in various cardiovascular diseases. (Pro)renin receptor (PRR) in performs as ligands in the autophagic process, and its function in diabetic ...
Xinyu Zhang, Xuefei Dong, Haipeng Jie, ShengNan Li, Hui-xin Li, Yudong Su, Lei Li, Li Kang, Bo Dong, Yun Zhang   +9 more
semanticscholar   +1 more source

Renin, Prorenin, and the (Pro)Renin Receptor

2009
The discovery of a receptor for renin and for its inactive precursor prorenin, and the introduction of renin inhibitors in therapeutic, has renewed the interest for the physiology of the renin angiotensin system (RAS) and has brought prorenin back in the spotlight.
Genevieve Nguyen, Aurelie Contrepas
openaire   +1 more source

The (pro)renin receptor ((P)RR) and soluble (pro)renin receptor (s(P)RR) in pregnancy

Placenta, 2021
The (pro)renin receptor ((P)RR) is a multi-functional protein that can be proteolytically cleaved and released in a soluble form (s(P)RR). Recently, the (P)RR and s(P)RR have become of interest in pregnancy and its associated pathologies. This is because the (P)RR not only activates tissue renin angiotensin systems, but it is also an integral component
Saije K Morosin, Alyssa J Lochrin, Sarah J Delforce   +2 more
exaly   +3 more sources