Results 281 to 290 of about 142,423 (312)
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Cellular Signalling
(Pro)renin receptor (PRR), along with its soluble form, sPRR, functions not only as a crucial activator of the local renin-angiotensin system but also engages with and activates various angiotensin II-independent signaling pathways, thus playing complex ...
Mengzhi Zhu +5 more
semanticscholar +1 more source
(Pro)renin receptor (PRR), along with its soluble form, sPRR, functions not only as a crucial activator of the local renin-angiotensin system but also engages with and activates various angiotensin II-independent signaling pathways, thus playing complex ...
Mengzhi Zhu +5 more
semanticscholar +1 more source
The (pro)renin receptor: therapeutic consequences
Expert Opinion on Investigational Drugs, 2006It is generally assumed that the beneficial effects of renin-angiotensin system blockers in cardiovascular disease are due to blockade of the generation or action of angiotensin at tissue sites. Such generation depends on the uptake of renin and/or its inactive precursor prorenin from the circulation.
Nguyen, G, Danser, Jan
openaire +2 more sources
Placenta, 2016
The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and
Atsuhiro Ichihara +2 more
exaly +3 more sources
The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and
Atsuhiro Ichihara +2 more
exaly +3 more sources
Physiology and pharmacology of the (pro)renin receptor
Current Opinion in Pharmacology, 2008The (pro)renin receptor [(P)RR] is a single trans-membrane domain receptor that mediates renin and prorenin specific effects. The receptor acts as co-factor for renin and prorenin by increasing their enzymatic activity on the cell-surface and it activates the mitogen activated protein kinases ERK1/2 cascade leading to cell proliferation and to up ...
Geneviève, Nguyen, Aurélie, Contrepas
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Nihon rinsho. Japanese journal of clinical medicine, 2009
Discovery of (pro)renin receptor elucidated that prorenin is not only an inactive precursor of renin but also an endocrine hormone. The binding of prorenin to the (pro) renin receptor triggers two major pathways: the angiotensin II-dependent pathway as a result of nonproteolytic activation of prorenin, and the angiotensin II-independent, (pro)renin ...
Atsuhiro, Ichihara, Hiroshi, Ito
openaire +1 more source
Discovery of (pro)renin receptor elucidated that prorenin is not only an inactive precursor of renin but also an endocrine hormone. The binding of prorenin to the (pro) renin receptor triggers two major pathways: the angiotensin II-dependent pathway as a result of nonproteolytic activation of prorenin, and the angiotensin II-independent, (pro)renin ...
Atsuhiro, Ichihara, Hiroshi, Ito
openaire +1 more source
Twenty years of the (pro)renin receptor
Journal of the American Society of Hypertension, 2008The (pro)renin receptor [(P)RR] specifically binds renin and prorenin and mediates their intracellular effects. It acts as co-factor for renin and prorenin by increasing their enzymatic activity on the cell-surface and it activates the mitogen activated protein kinases ERK1/2 (extracellular signal regulated kinase) cascade leading to cell proliferation
openaire +2 more sources
Cardiovascular aspects of the (pro)renin receptor: Function and significance
The FASEB Journal, 2022Chuanming Xu +3 more
semanticscholar +1 more source
(Pro)renin Receptor as a New Drug Target
Current Pharmaceutical Design, 2011Over the last few years, the implication of the (pro)renin receptor [(P)RR] in the pathogenesis of end-organ damage has been shown through many different studies. The (P)RR plays a dual role when stimulated by renin or prorenin as it enhances both cell surface production of angiotensin and stimulates angiotensin-independent intracellular signaling ...
Basma A M, Ahmed +2 more
openaire +2 more sources
Brain-Targeted (Pro)renin Receptor Knockdown Attenuates Angiotensin II–Dependent Hypertension
Hypertension, 2012Wencheng Li +2 more
exaly
Neuron-Specific (Pro)renin Receptor Knockout Prevents the Development of Salt-Sensitive Hypertension
Hypertension, 2014Wencheng Li +2 more
exaly