Results 71 to 80 of about 25,483,142 (313)

Existing approaches and trends in uncertainty modelling and probabilistic stability analysis of power systems with renewable generation

open access: yesRenewable & Sustainable Energy Reviews, 2019
The analysis of power systems with a significant share of renewable generation using probabilistic tools is essential to appropriately consider the impact that the variability and intermittency of the renewable generation has on the grid.
K. Hasan, R. Preece, J. Milanović
semanticscholar   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Risk analysis of the economic viability of feedlot aberdeen angus steers fed with different proportions of concentrate

open access: yesBioscience Journal, 2017
The economic viability of feedlot Aberdeen Angus steers fed with diets composed of different concentrate levels (CL) in dry matter (25, 40, 55 or 70%) was estimated using Monte Carlo simulation combined with Spearman rank correlation, considering nine ...
Joilmaro Rodrigo Pereira Rosa   +4 more
doaj  

Event‐Level Linkages Between Atmospheric Circulation and Anomalous Precipitation Types in a Typical East Asian Monsoon Basin

open access: yesGeophysical Research Letters
Anomalous precipitation, with unexpected intensity and/or spatiotemporal structures, makes flood risk management in the East Asian monsoon regions challenging, where interacting circulation systems generate highly variable precipitation events.
Wenpeng Zhao   +8 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Formulation of an optimal academic exam

open access: yesJournal of Computer Science and Technology, 2018
The aim of this paper is to formulate an optimal academic exam for a given subject. To do this, the probability is first modelled of a student passing the exam according to the number of units he studies and the professor evaluates. That simulation model
Enrique E. Tarifa   +3 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

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