Results 111 to 120 of about 387,004 (310)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Metode Markov Chain Untuk Prediksi Probing Terhadap Kinerja Promotor Pada Penjualan Oppo

Infotekmesin: Media Komunikasi Ilmiah Politeknik Cilacap, 2020
Jani Kusanti, Tri Irianto Tjendrowasono
doaj   +1 more source

Sub-THz Non-Contact Probing System for On-Chip Microfluidic Applications

IEEE Access
We present a novel sub-THz probe station enabling contact-free characterization of liquids within integrated microfluidic channels on quartz substrates.
Daniel Havelka, Petr Kurka, Karel Chadt, Jaroslav Havlicek, Kubilay Sertel, Michal Cifra   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Exploiting the Deep Web with DynaBot:

, 2008
We present the design of Dynabot, a guided Deep Web discovery system. Dynabot's modular architecture supports focused crawling of the Deep Web with an emphasis on matching, probing, and ranking discovered sources using two key components: service ...
Daniel Rocco, Matching Probing And
core  

Activatable smart contrast agents for photoacoustic imaging

Smart Molecules
Photoacoustic imaging (PAI) uniquely merges the molecular contrast of optical absorption with the centimeter‐scale penetration afforded by ultrasound detection, enabling noninvasive visualization of deep physiology beyond the reach of purely optical ...
Donghyeon Oh, Jihye Lee, Suyoung Park, Juyoung Yoon, Won Jong Kim, Chulhong Kim   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

The Effects of Quantity and Quality of Teachers’ Probing and Guiding Questions on Student Performance

Sakarya University Journal of Education, 2015
This study investigated the types, quantity, and quality of teacher questions and their impact on student understanding. In contrast to previous studies, in order to obtain optimum effects of question types, quantity, and quality, this study controlled ...
Alpaslan Sahin
doaj