Results 81 to 90 of about 335,473 (338)

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Weizmannia coagulans BC179 Alleviates Post-Alcohol Discomfort May via Taurine-Related Metabolism and Antioxidant Regulation: A Randomized, Double-Blind, Placebo-Controlled Trial

Antioxidants
Excessive alcohol consumption is associated with various health complications, including liver damage and systemic inflammation. Probiotic interventions have emerged as promising strategies to mitigate alcohol-induced harm, yet their mechanisms of action
Mengyao Duan, Ying Wu, Jie Zhang, Saman Azeem, Yao Dong, Zhonghui Gai, Jianguo Zhu, Shuguang Fang, Shaobin Gu   +8 more
doaj   +1 more source

Association between Yogurt Consumption and Intestinal Microbiota in Healthy Young Adults Differs by Host Gender

Frontiers in Microbiology, 2017
Human intestinal microbiota are influenced by various factors viz. diet, environment, age, gender, geographical, and socioeconomic situation, etc. among which diet has the most profound impact.
Yoshio Suzuki, Keiichi Ikeda, Kazuhiko Sakuma, Sachio Kawai, Keisuke Sawaki, Takashi Asahara, Takashi Asahara, Takuya Takahashi, Takuya Takahashi, Hirokazu Tsuji, Hirokazu Tsuji, Koji Nomoto, Koji Nomoto, Ravinder Nagpal, Chongxin Wang, Satoru Nagata, Satoru Nagata, Yuichiro Yamashiro   +17 more
doaj   +1 more source

Effect of short-term probiotic Enterococcus faecium SF68 dietary supplementation in overweight and obese cats without comorbidities [PDF]

, 2016
Obesity in cats is associated with metabolic abnormalities and increased susceptibility to diseases such as diabetes mellitus. Studies in mouse models and human beings have shown that probiotics can reduce food intake, promote weight loss and improve ...
Fascetti, A J, Kass, P H, Kathrani, A, Larsen, J A   +3 more
core   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Effect of Bifidobacterium animalis subsp. lactis Langg JZ-08 on lipid metabolism in individuals with obesity and dyslipidemia: A randomised, double-blind, and placebo-controlled trial

Human Nutrition & Metabolism
Dyslipidemia is an established risk factor for cardiovascular disease, especially for individuals with obesity. Probiotics have been studied for their potential lipid-lowering properties, but the evidence in individuals with obesity and dyslipidemia is ...
Xiaokang Niu, Qi Zhang, Yong Zhang, Ran Wang, Kai Yao, Yue Sang, Bing Fang, Yuyang Zhao, Liwei Liu, Langrun Wang, Rong Liu, Yixuan Li, Meiwen Sun, Hong Cui, Yinghua Liu, Jingjing He   +15 more
doaj   +1 more source

Ontogenesis of the Gut Microbiota Composition in Healthy, Full-Term, Vaginally Born and Breast-Fed Infants over the First 3 Years of Life: A Quantitative Bird’s-Eye View

Frontiers in Microbiology, 2017
Early-life intestinal microbiota development is crucial for host’s long-term health and is influenced by many factors including gestational age, birth and feeding modes, birth environment, ethnic/geographical background, etc. However, ‘quantitative’ data
Ravinder Nagpal, Hirokazu Tsuji, Hirokazu Tsuji, Takuya Takahashi, Takuya Takahashi, Koji Nomoto, Koji Nomoto, Kazunari Kawashima, Satoru Nagata, Yuichiro Yamashiro   +9 more
doaj   +1 more source

Competitive selection of lactic acid bacteria that persist in the human oral cavity [PDF]

, 2011
Lactic acid bacteria (LAB) might offer opportunities as oral probiotics provided candidate strains persist in the mouth. After intake of a mixture of 69 LAB, strains of Lactobacillus fermentum and Lactobacillus salivarius were especially recovered ...
Snel, J., Marco, M.L., Kingma, F., Noordman, W.M., Rademaker, J., Kleerebezem, M.   +5 more
core   +2 more sources

Unlocking the Potential of Probiotics: A Comprehensive Review on Research, Production, and Regulation of Probiotics

Probiotics and Antimicrobial Proteins
This review provides a comprehensive overview of the current state of probiotic research, covering a wide range of topics, including strain identification, functional characterization, preclinical and clinical evaluations, mechanisms of action ...
T. F. da Silva, R. Glória, M. Américo, A. Freitas, L. D. de Jesus, F. A. L. Barroso, J. Laguna, N. D. Coelho-Rocha, L. M. Tavares, Yves le Loir, Gwénaël Jan, Éric Guédon, V. Azevedo   +12 more
semanticscholar   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source