Results 151 to 160 of about 8,638,833 (269)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Procedural design in digital games: Space and environment interaction in No Man’s Sky

IDA: International Design and Art Journal
This study analyzes the effects of procedural design on the space and environment in No Man’s Sky. The research includes 300,000 comments from Steam gaming platform users between 2016 and 2024.
Onur Aşkın, Gülsüm Damla Aşkın
doaj   +2 more sources

BID Artifacts: An Artificial Intelligence-powered Briefing-Intraoperative-Debriefing Platform for Competency-based Plastic Surgery Education. [PDF]

Plast Reconstr Surg Glob Open
Duque-Ropero DF, Gómez-Samper AF.
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Bridging jurisdictions and legislatures: an LLM ensemble and arbiter framework for automated legal risk triage in digital media. [PDF]

Front Artif Intell
Lipianina-Honcharenko K, Drakokhrust T, Bykovyy P, Turchynov K, Ihnatiev I.   +4 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Executable explanation traces for legal LLM predictions via retrieval-augmented codification. [PDF]

Front Artif Intell
Chen H, Tanaka-Ishii K.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

LuminaConsent: AI-driven standardization and quality enhancement of urological informed consent documentation. [PDF]

North Clin Istanb
Topcu I, Soylu T, Simsekoglu MF, Tuzcu EM, Salman Z, Demir P, Kac B, Kartal MY, Suzan S, Karaman MI.   +9 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source