Results 71 to 80 of about 41,349 (293)
Planogen: A Procedural Generation Framework for Dynamic VR Research Environments
Virtual WorldsThis paper introduces Planogen, a modular procedural generation plug-in for the Unity game engine, which is composed of two primary components: a character generation module (CharGen) and an airplane generation module (PlaneGen). Planogen facilitates the
Kaitlyn Tracy +3 more
doaj +1 more source
Procedural Generation of Large-Scale Forests Using a Graph-Based Neutral Landscape Model
ISPRS International Journal of Geo-Information, 2018 Specifying the positions and attributes of plants (e.g., species, size, and height) during the procedural generation of large-scale forests in virtual geographic environments is challenging, especially when reflecting the characteristics of vegetation ...
Jiaqi Li +4 more
doaj +1 more source
Quantifying cumulative phenotypic and genomic evidence for procedural generation of metabolic network reconstructions. [PDF]
PLoS Comput Biol, 2022 Moutinho TJ +3 more
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Runner: A 2D platform game for physical health promotion
SoftwareX, 2019 Runner is a 2D platform game designed to be used for conducting research studies on health promotion. This paper presents basic features of the game and describes how contents are procedurally generated.
Camille El-Habr +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
ATLAS CHRONICLE: DEVELOPMENT AND VERIFICATION OF A SYSTEM FOR PROCEDURAL GENERATION OF STORY-DRIVEN GAMES [PDF]
, 2020 Elizabeth Matthews, Juan E. Gilbert
openalex +1 more source
BraidNet: procedural generation of neural networks for image classification problems using braid theory [PDF]
, 2021 Olga Lukyanova +2 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source