Results 81 to 90 of about 2,908,953 (289)
Procedural Fairness and the Institutional Dynamic: Where We Are and Where We Should Be Going
, 2017 The chapters in this volume have sought to provide a better understanding of procedural fairness within the international system. Our aims have been restrained given that the research agenda here is new: we have not sought to offer a “universal model” of
Sarvarian, A, Baker, RB
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Procedural generation of cities [PDF]
, 2016 Käesolevas bakalaureusetöös kirjeldatakse eksisteerivaid linnade genereerimise süsteeme ning nende põhjal autori poolt väljatöötatud linnade genereerimise süsteemi.
Perli, Kristjan
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Multi-task procedural content generation with reinforcement learning
Scientific ReportsThis paper presents a multi-task language-based framework for procedural content generation through reinforcement learning, which aims to improve the semantic alignment between linguistic commands and quantitative game surface features.
Aylin Nekahdari +4 more
doaj +1 more source
MOPCGRL: Multi-Objective Procedural Content Generation via Reinforcement Learning
Complex System Modeling and SimulationOnline content generation enables automatic and adaptive creation of diverse and playable game content for maximizing player experience or testing Artificial Intelligence (AI) algorithms.
Yi Yuan +7 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Procedural generation of aesthetic patterns from dynamics and iteration processes
International Journal of Applied Mathematics and Computer Science, 2017 Aesthetic patterns are widely used nowadays, e.g., in jewellery design, carpet design, as textures and patterns on wallpapers, etc. Most of the work during the design stage is carried out by a designer manually.
Gdawiec Krzysztof
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source