Results 91 to 100 of about 4,305,606 (328)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Modern Trends in the Automatic Generation of Content for Video Games [PDF]

, 2016
Attractive and realistic content has always played a crucial role in the penetration and popularity of digital games, virtual environments, and other multimedia applications.
Bontchev, Boyan
core  

An output-sensitive algorithm for the minimization of 2-dimensional String Covers

, 2019
String covers are a powerful tool for analyzing the quasi-periodicity of 1-dimensional data and find applications in automata theory, computational biology, coding and the analysis of transactional data. A \emph{cover} of a string $T$ is a string $C$ for
A Apostolico, A Apostolico, A Bacciotti, A Katok, A Muchnik, A Tychonoff, A Wlodawer, AK Brodzik, AV Aho, DE Knuth, J Kopf, JR Searle, K Perlin, L Bursill, R Middlestead, RS Bird, S Havlin, WA Sethares   +17 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Quantifying cumulative phenotypic and genomic evidence for procedural generation of metabolic network reconstructions. [PDF]

PLoS Comput Biol, 2022
Moutinho TJ, Neubert BC, Jenior ML, Papin JA.   +3 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

MOPCGRL: Multi-Objective Procedural Content Generation via Reinforcement Learning

Complex System Modeling and Simulation
Online content generation enables automatic and adaptive creation of diverse and playable game content for maximizing player experience or testing Artificial Intelligence (AI) algorithms.
Yi Yuan, Qingquan Zhang, Bo Yuan, Matthew Barthet, Ahmed Khalifa, Georgios N. Yannakakis, Huanhuan Chen, Jialin Liu   +7 more
doaj   +1 more source

On the Evaluation of Procedural Level Generation Systems [PDF]

International Conference on Foundations of Digital Games
The evaluation of procedural content generation (PCG) systems for generating video game levels is a complex and contested topic. Ideally, the field would have access to robust, generalisable and widely accepted evaluation approaches that can be used to ...
Oliver Withington, Michael Cook, L. Tokarchuk   +2 more
semanticscholar   +1 more source

Process, People, Power and Policy: Empirical Studies of Civil Procedure and Courts [PDF]

, 2010
This review essay, by Professor Carrie Menkel-Meadow and Dean Bryant Garth, reports on the history and deployment of empirical studies of civil procedure rules, court policies, and legal developments for reforms of court procedures and practices in both ...
Garth, Bryant, Menkel-Meadow, Carrie
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source