Results 111 to 120 of about 2,908,953 (289)

Generation R

, 2022
Generation R onderzoekt de groei, ontwikkeling en gezondheid van 10.000 opgroeiende kinderen in Rotterdam (prospective cohort study). Deze kinderen worden al gevolgd vanaf de vroege zwangerschap en blijven we volgen tot hun jong volwassenheid.
Erasmus MC, afdeling Generation R
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Procedural generation as an approach for digital representation of a city

Computational Urban Science
Digital 3D city models support urban planning, simulation, and immersive applications, but common production methods such as manual CAD modelling, photogrammetry/LiDAR, and GIS-based extrusion are often slow, costly, difficult to scale, and hard to ...
Farshad Shariatpour, Amir Shakibamanesh, Morteza Rahbar   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

PRAG: Procedural Action Generator

CoRR
We present a novel approach for the procedural construction of multi-step contact-rich manipulation tasks in robotics. Our generator takes as input user-defined sets of atomic actions, objects, and spatial predicates and outputs solvable tasks of a given length for the selected robotic environment.
Michal Vavrecka, Radoslav Skoviera, Gabriela Sejnova, Karla Stépánová   +3 more
openaire   +2 more sources

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

A deep generative approach to personalized super mario level design

Scientific Reports
Designing game levels that appropriately match a player’s skill level remains a fundamental challenge in procedural content generation, as mismatches in difficulty can lead to player boredom, frustration, and reduced engagement.
Deniz Baharvand, Nima Saeedi, Sina Samadi Gharehveran, Kimia Shirini   +3 more
doaj   +1 more source

TexPro: Text-guided PBR texturing with procedural material modeling

Computational Visual Media
In this paper, we present TexPro, a novel method for high-fidelity material generation for input 3D meshes given text prompts. Unlike existing text-conditioned texture generation methods that typically generate RGB textures with baked lighting, TexPro is
Ziqiang Dang, Wenqi Dong, Zesong Yang, Bangbang Yang, Liang Li, Yuewen Ma, Zhaopeng Cui   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

AutoSceCraft: Generate Various Driving Scenarios from Scratch for Autonomous Driving Systems

Tsinghua Science and Technology
Autonomous Driving Systems (ADS) are safety-critical. Abundant and various driving scenarios are required to train accurate and robust models, and comprehensively test each module of autonomous driving systems (i.e., perception, tracking, prediction ...
Wenxing Lan, Jialin Liu, Bo Yuan, Xin Yao   +3 more
doaj   +1 more source