Results 11 to 20 of about 128,839 (232)

Real-time quality control for chemical and biotechnological processes: a brief review

Journal of Medical Science, 2023
Monitoring critical process parameters of chemical and biotechnological processes is an essential tool at every stage of drug manufacturing technology.
Agnieszka Kołodziejczak-Radzimska, Beata Rukowicz, Sharon Davin   +2 more
doaj   +1 more source

Fast and Non-Invasive Evaluation of Yeast Viability in Fermentation Processes Using Raman Spectroscopy and Machine Learning

Beverages, 2023
Fermentation processes used for producing alcoholic beverages such as beer, wine, and cider have a long history, having been developed early on across different civilizations. In most instances, yeast strains are used for fermentation processes, e.g., at
Raoul Heese, Jens Wetschky, Carina Rohmer, Susanne M. Bailer, Michael Bortz   +4 more
doaj   +1 more source

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

Pharmaceutics, 2021
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry.
Eun Ji Kim, Ji Hyeon Kim, Min-Soo Kim, Seong Hoon Jeong, Du Hyung Choi   +4 more
doaj   +1 more source

The Rocky Road to a Digital Lab

CHIMIA, 2023
The pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs).
Peter Sagmeister, Jason D. Williams, C. Oliver Kappe   +2 more
doaj   +1 more source

In Situ Quantification of Polyhydroxybutyrate in Photobioreactor Cultivations of Synechocystis sp. Using an Ultrasound-Enhanced ATR-FTIR Spectroscopy Probe

Bioengineering, 2021
Polyhydroxybutyrate (PHB) is a very promising alternative to most petroleum-based plastics with the huge advantage of biodegradability. Biotechnological production processes utilizing cyanobacteria as sustainable source of PHB require fast in situ ...
Philipp Doppler, Christoph Gasser, Ricarda Kriechbaum, Ardita Ferizi, Oliver Spadiut   +4 more
doaj   +1 more source

Measurement of Paracetamol Concentration Using an Erbium-Doped Fiber Ring Cavity

Photonics, 2023
Process Analytical Technology (PAT) has been increasingly used in the pharmaceutical industry to monitor essential parameters in real-time during pharmaceutical processes. The concentration of Active Pharmaceutical Ingredients (APIs), such as paracetamol,
Liliana Soares, Rosa Ana Pérez-Herrera, Susana Novais, António Ferreira, Susana Silva, Orlando Frazão   +5 more
doaj   +1 more source

BioTech 2017 Conference Report, Wädenswil, 7./8.9.2017

CHIMIA, 2017
Almost 200 scientists and professionals from academia and industry attended the BioTech 2017 conference at the Zurich University of Applied Sciences (ZHAW) in Wädenswil on 7./8. September 2017.
Caspar Demuth
doaj   +1 more source

Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors

Sensors, 2022
Raman spectroscopy is an analytical technology for the simultaneous measurement of important process parameters, such as concentrations of nutrients, metabolites, and product titer in mammalian cell culture.
Alexander Graf, Angus Woodhams, Michael Nelson, Douglas D. Richardson, Steven M. Short, Mark Brower, Marek Hoehse   +6 more
doaj   +1 more source

Real-time assessment of critical quality attributes of a continuous granulation process [PDF]

, 2013
There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off ...
Córdoba Díaz, Damián, De Beer, Thomas, Fonteyne, Margot, Gildemyn, Delphine, Remon, Jean Paul, Vercruysse, Jurgen, Vervaet, Chris   +6 more
core   +1 more source

Development and Validation of an In‐Line API Quantification Method Using AQbD Principles Based on UV‐Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Process [PDF]

, 2020
open access journalA key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls.
Almeida, Juan, Berghaus, Andreas, Bezerra, Mariana, Borman, Phil, Markl, Daniel, Schlindwein, W. S.   +5 more
core   +2 more sources