Results 21 to 30 of about 130,011 (340)

BioTech 2017 Conference Report, Wädenswil, 7./8.9.2017

CHIMIA, 2017
Almost 200 scientists and professionals from academia and industry attended the BioTech 2017 conference at the Zurich University of Applied Sciences (ZHAW) in Wädenswil on 7./8. September 2017.
Caspar Demuth
doaj   +1 more source

Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors

Sensors, 2022
Raman spectroscopy is an analytical technology for the simultaneous measurement of important process parameters, such as concentrations of nutrients, metabolites, and product titer in mammalian cell culture.
Alexander Graf, Angus Woodhams, Michael Nelson, Douglas D. Richardson, Steven M. Short, Mark Brower, Marek Hoehse   +6 more
doaj   +1 more source

Real-time assessment of critical quality attributes of a continuous granulation process [PDF]

, 2013
There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off ...
Córdoba Díaz, Damián, De Beer, Thomas, Fonteyne, Margot, Gildemyn, Delphine, Remon, Jean Paul, Vercruysse, Jurgen, Vervaet, Chris   +6 more
core   +1 more source

Demonstrating Functional Equivalence of Pilot and Production Scale Freeze-Drying of BCG. [PDF]

PLoS ONE, 2016
Process analytical technology (PAT)-tools were used to monitor freeze-drying of Bacille Calmette-Guérin (BCG) at pilot and production scale. Among the evaluated PAT-tools, there is the novel use of the vacuum valve open/close frequency for determining ...
R Ten Have, K Reubsaet, P van Herpen, G Kersten, J-P Amorij   +4 more
doaj   +1 more source

Fluorescence-based analyser as a rapid tool for determining soluble protein content in dairy ingredients and infant milk formula [PDF]

, 2018
peer-reviewedAbstract: Milk protein, in particular native whey protein, is of interest to dairy manufacturers as a measure of functional and nutritional quality.
Esquerre, Carlos, Henihan, Lisa E., Murphy, Eoin, O'Callaghan, Donal, O'Donnell, Colm P.   +4 more
core   +1 more source

Advances in Twin-Screw Granulation Processing

Pharmaceutics, 2021
Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms.
Uttom Nandi, Vivek Trivedi, Steven A. Ross, Dennis Douroumis   +3 more
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Understanding Pharmaceutical Quality by Design [PDF]

, 2016
This review further clarifies the concept of pharmaceutical quality by design (QbD) and describes its objectives. QbD elements include the following: (1) a quality target product profile (QTPP) that identifies the critical quality attributes (CQAs) of ...
Amidon, Gregory, Hoag, Stephen W., Khan, Mansoor A., Polli, James, Raju, Gokaraju K, Woodcock, Janet, Yu, Lawrence X.   +6 more
core   +1 more source

Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model for Different Cores

Pharmaceutics, 2020
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications.
Juliana Radtke, Hubertus Rehbaum, Peter Kleinebudde   +2 more
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Removal of benzaldehyde from a water/ethanol mixture by applying scavenging techniques

Green Processing and Synthesis, 2017
A presence of carbonyl compounds is very common in the food industry. The nature of such compounds is to be reactive and thus many products involve aldehydes/ketones in their synthetic routes.
Mitic Aleksandar, Skov Thomas, Gernaey Krist V.   +2 more
doaj   +1 more source

Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Scientific Reports, 2023
Process analytical technology (PAT) has demonstrated huge potential to enable the development of improved biopharmaceutical manufacturing processes by ensuring the reliable provision of quality products.
Thomas Williams, Kevin Kalinka, Rui Sanches, Greg Blanchard-Emmerson, Samuel Watts, Lee Davies, Carol Knevelman, Laura McCloskey, Peter Jones, Kyriacos Mitrophanous, James Miskin, Duygu Dikicioglu   +11 more
doaj   +1 more source