Results 61 to 70 of about 130,011 (340)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Agglomeration Control during Ultrasonic Crystallization of an Active Pharmaceutical Ingredient

Crystals, 2017
Application of ultrasound during crystallization can efficiently inhibit agglomeration. However, the mechanism is unclear and sonication is usually enabled throughout the entire process, which increases the energy demand. Additionally, improper operation
Bjorn Gielen, Jeroen Jordens, Leen C. J. Thomassen, Leen Braeken, Tom Van Gerven   +4 more
doaj   +1 more source

Establishment of a continuous sonocrystallization process for lactose in an oscillatory baffled crystallizer [PDF]

, 2015
Crystallization at production scale (>10 kg) is typically a poorly understood unit operation with limited application of first-principles understanding of crystallization to routine design, optimization, and control.
Brown, Cameron J., Florence, Alastair J., Houson, Ian, Siddique, Humera   +3 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Aplicación de métodos matemáticos y estadísticos en la industria The application of mathematical and statistical methods in industry

Revista Técnica de la Facultad de Ingeniería, 2010
La Quimiometría ha sido definida como “la disciplina que utiliza métodos matemáticos y estadísticos para seleccionar o diseñar procedimientos y experimentos óptimos, y proveer información relevante a partir de datos químicos”.
Carlos Alciaturi, Marcos Escobar, Iván Esteves, Zoilabet Duque   +3 more
doaj  

Process analytical technology tools for perfusion cell culture

Engineering in Life Sciences, 2016
During cell cultivation processes for the production of biopharmaceuticals, good process performance and good product quality can be ensured by online monitoring of critical process parameters (e.g. temperature, pH, or dissolved oxygen).
Sarah M. Mercier, Perrine M. Rouel, Pierre Lebrun, Bas Diepenbroek, René H. Wijffels, Mathieu Streefland   +5 more
doaj   +1 more source

A BRIEF REVIEW ON PROCESS ANALYTICAL TECHNOLOGY (PAT) [PDF]

, 2016
Process analytical technology (PAT) has been defined as a mechanism to design, analyze and control pharmaceutical manufacturing processes through measurement of critical process parameters which affect critical quality attributes.
Jagtap, Monali, Karekar, P., Mali, Akash S., MARUSKA, A.   +3 more
core  

Pattern formation in a ring cavity with temporally incoherent feedback [PDF]

, 2004
We present a theoretical and experimental study of modulation instability and pattern formation in a passive nonlinear optical cavity that is longer than the coherence length of the light circulating in it.
Buljan, Hrvjoe, Carmon, Tal, Cohen, Oren, Fleischer, Jason W., Schwartz, Tal, Segev, Mordechai   +5 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source