Results 121 to 130 of about 2,971 (153)
PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer [PDF]
Pharmaceuticals, 2021 Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood.
Wojciech Miltyk +2 more
exaly +5 more sources
International Journal of Molecular Sciences, 2022 The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells.
Wojciech Miltyk +2 more
exaly +2 more sources
P5CDH Affects the Pathways Contributing to Pro Synthesis After ProDH Activation by Biotic and Abiotic Stress Conditions [PDF]
Frontiers in Plant Science, 2015 Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ1 pyrroline-5-
María Elena Alvarez +2 more
exaly +7 more sources
Journal of Clinical Medicine, 2021 The impact of estradiol on troglitazone (TGZ)-induced proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied in wild-type and PRODH/POX-silenced estrogen receptor (ER) dependent MCF-7 cells and ER-independent MDA-MB-231 cells ...
Izabela Prokop +2 more
exaly +2 more sources
Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells
Frontiers in Molecular Biosciences, 2022 Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ligands (implicated in the regulation of cancer cell survival/apoptosis), the effect of MET on PRODH ...
Wojciech Miltyk +2 more
exaly +4 more sources
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PRODH Variants and Risk for Schizophrenia
Amino Acids, 2008Schizophrenia is a common, devastating neuropsychiatric disorder whose etiology is largely unknown. Multiple studies in humans and in mouse and fly models suggest a role for proline and PRODH, the gene encoding the first enzyme in the pathway of proline catabolism, in contributing risk for schizophrenia.
David Valle, Gary Steel
exaly +3 more sources
Biomolecules, 2021 It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). The aim of this study is identification of key metabolites of glycolysis, pentose phosphate pathway (PPP ...
Thi Yen Ly Huynh +2 more
exaly +2 more sources
EMBO ReportsNaive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood.
Meihua Sui, Ying-Jie Wang, Cheng Chen
exaly +2 more sources
Early Neurological Phenotype in 4 Children With Biallelic PRODH Mutations
Brain and Development, 2007Hyperprolinemia type I (HPI) results from a deficiency of proline oxidase (POX), involved in the first step in the conversion of proline to glutamate. Diverse phenotypes were described in patients with HPI, prior to the identification of the POX gene (PRODH): whereas various patients were asymptomatic, others had neurological and extraneurological ...
Heron Delphine +2 more
exaly +3 more sources
Proline Metabolism Reprogramming in Cancer Reveals the Regulation of PRODH/POX as Target
Biomedicine and PharmacotherapyProline dehydrogenase (PRODH) plays a dual role in cancer by catalyzing the first step of proline catabolism. During tumor metabolic reprogramming, PRODH catalyzes the conversion of proline to Δ¹-pyrroline-5-carboxylate (P5C), which enters the tricarboxylic acid cycle and supports cancer cell growth and energy supply. However, the increased activity of
Quanjun Yang, Yuxuan Zhou
exaly +3 more sources