Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart. [PDF]
Sci AdvLv Q +11 more
europepmc +1 more source
The acoustic startle response in 22q11 deletion syndrome: from animal models to humans. [PDF]
Front NeurosciImes S +5 more
europepmc +1 more source
Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line [PDF]
International Journal of Molecular Sciences, 2022 The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells.
Wojciech Miltyk +2 more
exaly +2 more sources
Troglitazone-Induced PRODH/POX-Dependent Apoptosis Occurs in the Absence of Estradiol or ERβ in ER-Negative Breast Cancer Cells [PDF]
Journal of Clinical Medicine, 2021 The impact of estradiol on troglitazone (TGZ)-induced proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied in wild-type and PRODH/POX-silenced estrogen receptor (ER) dependent MCF-7 cells and ER-independent MDA-MB-231 cells ...
Izabela Prokop-Bielenia +2 more
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PRODH variants and risk for schizophrenia
Amino Acids, 2008Schizophrenia is a common, devastating neuropsychiatric disorder whose etiology is largely unknown. Multiple studies in humans and in mouse and fly models suggest a role for proline and PRODH, the gene encoding the first enzyme in the pathway of proline catabolism, in contributing risk for schizophrenia.
David Valle, Valle David
exaly +3 more sources
Early neurological phenotype in 4 children with biallelic PRODH mutations
Brain and Development, 2007Hyperprolinemia type I (HPI) results from a deficiency of proline oxidase (POX), involved in the first step in the conversion of proline to glutamate. Diverse phenotypes were described in patients with HPI, prior to the identification of the POX gene (PRODH): whereas various patients were asymptomatic, others had neurological and extraneurological ...
Lydie Bürglen +2 more
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Cognitive impairment in schizophrenia (SCZ) is a core feature, relevant for the disease prognosis and functional capacity of the patients. It has also been identified as an endophenotype and proposed as a genetic mechanism of risk for schizophrenia.We aimed to evaluate the association of genetic variants in COMT, PRODH, and DISC1 with the cognitive ...
Ingrid Fricke-Galindo +8 more
openaire +2 more sources
Proline metabolism reprogramming in cancer reveals the regulation of PRODH/POX as target
Biomedicine and PharmacotherapyProline dehydrogenase (PRODH) plays a dual role in cancer by catalyzing the first step of proline catabolism. During tumor metabolic reprogramming, PRODH catalyzes the conversion of proline to Δ¹-pyrroline-5-carboxylate (P5C), which enters the tricarboxylic acid cycle and supports cancer cell growth and energy supply. However, the increased activity of
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Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia
Genes, Brain and Behavior, 2007Haploinsufficiency of 22q11 genes including catechol‐O‐methyltransferase (COMT) and proline dehydrogenase (PRODH) may result in structural and functional brain abnormalities and increased vulnerability to schizophrenia as observed in patients with microdeletions of 22q11. Thus, COMT and PRODH could be modifier genes for schizophrenia.
Zinkstok, J. +5 more
openaire +3 more sources
A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population [PDF]
Psychiatry Research, 2007 Previous studies have suggested that catechol-O-methyltransferase (COMT), proline dehydrogenase (PRODH), and brain-derived neurotrophic factor (BDNF) genes are possible susceptibility genes for schizophrenia.
, Tao Li, David A Collier
exaly +2 more sources