Results 151 to 160 of about 2,833 (174)

Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells

Frontiers in Molecular Biosciences, 2022
Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ...
Thi Yen Ly Huynh, Ilona Zaręba, Lukasz Szoka   +2 more
exaly   +5 more sources

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PRODH variants and risk for schizophrenia

Amino Acids, 2008
Schizophrenia is a common, devastating neuropsychiatric disorder whose etiology is largely unknown. Multiple studies in humans and in mouse and fly models suggest a role for proline and PRODH, the gene encoding the first enzyme in the pathway of proline catabolism, in contributing risk for schizophrenia.
Hans-Ulrich Bender, David Valle, Valle David   +2 more
exaly   +3 more sources

Prognostic and immunomodulatory roles of schizophrenia-associated genes HTR2A, COMT, and PRODH in pan-cancer analysis and glioma survival prediction model

Frontiers in Immunology, 2023
BackgroundThe shortened life expectancy in schizophrenia (SCZ) patients may be correlated with most cancers, yet there is heterogeneity in the studies examining these correlations. This study explored the expression of SCZ-related genes (HTR2A, COMT, and
Jing Shen, Qiang Wang, Fengquan Lu, Hua Xu, Peng Wang, Yu Feng, Yu Feng, Yu Feng   +7 more
exaly   +3 more sources

Early neurological phenotype in 4 children with biallelic PRODH mutations

Brain and Development, 2007
Hyperprolinemia type I (HPI) results from a deficiency of proline oxidase (POX), involved in the first step in the conversion of proline to glutamate. Diverse phenotypes were described in patients with HPI, prior to the identification of the POX gene (PRODH): whereas various patients were asymptomatic, others had neurological and extraneurological ...
Alexandra Afenjar, Diane Doummar, Daniel Rabier   +2 more
exaly   +3 more sources

Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia

Archives of Medical Research, 2022
Cognitive impairment in schizophrenia (SCZ) is a core feature, relevant for the disease prognosis and functional capacity of the patients. It has also been identified as an endophenotype and proposed as a genetic mechanism of risk for schizophrenia.We aimed to evaluate the association of genetic variants in COMT, PRODH, and DISC1 with the cognitive ...
Ingrid Fricke-Galindo, Blanca E. Pérez-Aldana, Luis R. Macías-Kauffer, Susana González-Arredondo, David Dávila-Ortiz de Montellano, Carlos L. Aviña-Cervantes, Marisol López-López, Yaneth Rodríguez-Agudelo, Nancy Monroy-Jaramillo   +8 more
openaire   +2 more sources

Proline metabolism reprogramming in cancer reveals the regulation of PRODH/POX as target

Biomedicine and Pharmacotherapy
Proline dehydrogenase (PRODH) plays a dual role in cancer by catalyzing the first step of proline catabolism. During tumor metabolic reprogramming, PRODH catalyzes the conversion of proline to Δ¹-pyrroline-5-carboxylate (P5C), which enters the tricarboxylic acid cycle and supports cancer cell growth and energy supply. However, the increased activity of
Quanjun Yang
exaly   +3 more sources

Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia

Genes, Brain and Behavior, 2007
Haploinsufficiency of 22q11 genes including catechol‐O‐methyltransferase (COMT) and proline dehydrogenase (PRODH) may result in structural and functional brain abnormalities and increased vulnerability to schizophrenia as observed in patients with microdeletions of 22q11. Thus, COMT and PRODH could be modifier genes for schizophrenia.
Zinkstok, J., Schmitz, N., van Amelsvoort, T., Moeton, M., Baas, F., Linszen, D.   +5 more
openaire   +3 more sources

Proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia susceptibility: a meta-analysis

Metabolic Brain Disease, 2017
Previous studies have been conducted to explore the association between proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia (SZ) susceptibility, but providing the controversial results. Here we performed this meta-analysis to determine whether PRODH variants were associated with SZ risk.
Xingzhi, Guo, Peng, Tang, Caiping, Yang, Rui, Li   +3 more
openaire   +2 more sources

A Risk PRODH Haplotype Affects Sensorimotor Gating, Memory, Schizotypy, and Anxiety in Healthy Male Subjects

Biological Psychiatry, 2009
Significant associations have been shown for haplotypes comprising three PRODH single nucleotide polymorphisms (SNPs; 1945T/C, 1766A/G, 1852G/A) located in the 3' region of the gene, suggesting a role of these variants in the etiopathogenesis of schizophrenia.
Panos Roussos, Stella G Giakoumaki, Panos Bitsios   +2 more
exaly   +3 more sources

Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes

Journal of Psychiatric Research, 2013
22q11.2 deletion syndrome (22q11.2DS) is a common genetic risk factor for the development of schizophrenia. We investigated two neurophysiological endophenotypes of schizophrenia - P50 sensory gating and mismatch negativity in 22q11.2DS subject and evaluated their association with catechol O-methyltransferase (COMT) and proline dehydrogenase (PRODH ...
Omer, Zarchi, Miri, Carmel, Chen, Avni, Josef, Attias, Amos, Frisch, Elena, Michaelovsky, Miriam, Patya, Tamar, Green, Ronnie, Weinberger, Abraham, Weizman, Doron, Gothelf   +10 more
openaire   +2 more sources