Results 171 to 180 of about 4,962 (199)

A Risk PRODH Haplotype Affects Sensorimotor Gating, Memory, Schizotypy, and Anxiety in Healthy Male Subjects

Biological Psychiatry, 2009
Significant associations have been shown for haplotypes comprising three PRODH single nucleotide polymorphisms (SNPs; 1945T/C, 1766A/G, 1852G/A) located in the 3' region of the gene, suggesting a role of these variants in the etiopathogenesis of schizophrenia.
Panagiotis Roussos, Stella G Giakoumaki
exaly   +3 more sources

Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2003
AbstractPeople with deletion of the chromosome 22q11 region associated with velo cardio‐facial syndrome (VCFS) have a remarkably high risk of developing schizophrenia. Recently, the gene proline dehydrogenase (PRODH) which maps to 22q11 and is also an excellent functional candidate gene for psychosis, has been reported to show genetic association with ...
Williams, H.J., Williams, Nigel Melville, Spurlock, G., Norton, N., Zammit, Stanley, Kirov, George, Owen, Michael John, O'Donovan, Michael Conlon   +7 more
openaire   +3 more sources

Proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia susceptibility: a meta-analysis

Metabolic Brain Disease, 2017
Previous studies have been conducted to explore the association between proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia (SZ) susceptibility, but providing the controversial results. Here we performed this meta-analysis to determine whether PRODH variants were associated with SZ risk.
Xingzhi, Guo, Peng, Tang, Caiping, Yang, Rui, Li   +3 more
openaire   +2 more sources

Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

Psychiatric Genetics, 2006
Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play
Prata, Diana, Breen, G, Munro, J, Sinclair, M, Osborne, S, Li, T, Kerwin, R, Clair, D S, Collier, D A   +8 more
openaire   +3 more sources

In silico Analysis of PRODH Mutations and their biological significance in disease etiology

Abasyn Journal Life Sciences, 2022
In the present study, we performed in silico analysis on all reported mutations of PRODH in order to investigate their biological significance. 3D models of wildtype and mutant PRODH were predicted using I-TASSER. Protein-protein docking was done with Cluspro, while protein-substrate docking was done with Auto Dock tools.
Muhammad Muzammal, Muzammil Ahmad Khan, Sana Fatima, Abida Bibi, Shahzadi Raheela Anum, Sumra Wajid Abbasi, Ansar Ahmad Abbasi, Iftikhar Ahmed, Syed Shakil Abbas   +8 more
openaire   +1 more source

Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia

Genes, Brain and Behavior, 2007
Haploinsufficiency of 22q11 genes including catechol‐O‐methyltransferase (COMT) and proline dehydrogenase (PRODH) may result in structural and functional brain abnormalities and increased vulnerability to schizophrenia as observed in patients with microdeletions of 22q11. Thus, COMT and PRODH could be modifier genes for schizophrenia.
Zinkstok, J., Schmitz, N., van Amelsvoort, T., Moeton, M., Baas, F., Linszen, D.   +5 more
openaire   +3 more sources

Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes

Journal of Psychiatric Research, 2013
22q11.2 deletion syndrome (22q11.2DS) is a common genetic risk factor for the development of schizophrenia. We investigated two neurophysiological endophenotypes of schizophrenia - P50 sensory gating and mismatch negativity in 22q11.2DS subject and evaluated their association with catechol O-methyltransferase (COMT) and proline dehydrogenase (PRODH ...
Omer, Zarchi, Miri, Carmel, Chen, Avni, Josef, Attias, Amos, Frisch, Elena, Michaelovsky, Miriam, Patya, Tamar, Green, Ronnie, Weinberger, Abraham, Weizman, Doron, Gothelf   +10 more
openaire   +2 more sources

Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004
AbstractHaploinsufficiency for or mutation in at least one gene from the velocardiofacial syndrome (VCFS) region at chromosome 22q11 is implicated in psychosis. Linkage disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al., 2002a] and by analysis of
Collier, DA, Ma, X, Li, T, Sham, PC, Sun, X, Hu, X, Wang, Q, Meng, H, Deng, W, Liu, X, Murray, RM   +10 more
openaire   +4 more sources

Identification of PRODH mutations in Korean neonates with type I hyperprolinemia.

Annals of clinical and laboratory science, 2013
Hyperprolinemia is a rare inherited metabolic disorder characterized by a high proline level in blood and/or urine and various neuropsychiatric symptoms. Type I hyperprolinemia is caused by a proline oxidase deficiency, which is encoded by the PRODH gene on chromosome 22q11.
Mi-Ae, Jang, Byung Cheol, Kim, Chang-Seok, Ki, Soo-Youn, Lee, Jong-Won, Kim, Tae Youn, Choi, Dong Hwan, Lee, Junghan, Song, Yong-Wha, Lee, Hyung-Doo, Park   +9 more
openaire   +1 more source

Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects

Journal of Psychiatric Research, 2014
The 22q11.2 deletion syndrome (22q11.2DS) carries the highest genetic risk factor for the development of schizophrenia. We investigated the association of genetic variants in two schizophrenia candidate genes with executive function (EF) and IQ in 22q11.2DS individuals.
Miri, Carmel, Omer, Zarchi, Elena, Michaelovsky, Amos, Frisch, Miriam, Patya, Tamar, Green, Doron, Gothelf, Abraham, Weizman   +7 more
openaire   +2 more sources