Results 161 to 170 of about 4,962 (199)

Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart. [PDF]

open access: yesSci Adv
Lv Q   +10 more
europepmc   +1 more source

PRODH variants and risk for schizophrenia

Amino Acids, 2008
Schizophrenia is a common, devastating neuropsychiatric disorder whose etiology is largely unknown. Multiple studies in humans and in mouse and fly models suggest a role for proline and PRODH, the gene encoding the first enzyme in the pathway of proline catabolism, in contributing risk for schizophrenia.
David Valle
exaly   +3 more sources

Context of action of Proline Dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis [PDF]

open access: yesBMC Plant Biology, 2014
La proline (Pro) déshydrogénase (ProDH) potentialise l'éclatement oxydatif et la mort cellulaire de la réponse hypersensible (RH) de la plante par des mécanismes non encore élucidés. ProDH convertit Pro en ∆1 pyrroline-5-carboxylate (P5C) et peut agir conjointement avec la P5C déshydrogénase (P5CDH) pour produire Glu, ou avec la P5C réductase (P5CR ...
Mariela Ines Monteoliva   +2 more
exaly   +4 more sources

PRODH gene is associated with executive function in schizophrenic families

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractThe aim of this study was to investigate the relationship between polymorphisms in the PRODH and COMT genes and selected neurocognitive functions. Six SNPs in PRODH and two SNPs in COMT were genotyped in 167 first‐episode schizophrenic families who had been assessed by a set of 14 neuropsychological tests.
Li, T   +9 more
openaire   +5 more sources

Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia

Archives of Medical Research, 2022
Cognitive impairment in schizophrenia (SCZ) is a core feature, relevant for the disease prognosis and functional capacity of the patients. It has also been identified as an endophenotype and proposed as a genetic mechanism of risk for schizophrenia.We aimed to evaluate the association of genetic variants in COMT, PRODH, and DISC1 with the cognitive ...
Ingrid Fricke-Galindo   +8 more
openaire   +2 more sources

Early neurological phenotype in 4 children with biallelic PRODH mutations

Brain and Development, 2007
Hyperprolinemia type I (HPI) results from a deficiency of proline oxidase (POX), involved in the first step in the conversion of proline to glutamate. Diverse phenotypes were described in patients with HPI, prior to the identification of the POX gene (PRODH): whereas various patients were asymptomatic, others had neurological and extraneurological ...
Alexandra, Afenjar   +12 more
exaly   +3 more sources

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