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Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects

Journal of Psychiatric Research, 2014
The 22q11.2 deletion syndrome (22q11.2DS) carries the highest genetic risk factor for the development of schizophrenia. We investigated the association of genetic variants in two schizophrenia candidate genes with executive function (EF) and IQ in 22q11.2DS individuals.
Miri, Carmel +7 more
openaire +2 more sources

Identification of PRODH mutations in Korean neonates with type I hyperprolinemia.

Annals of clinical and laboratory science, 2013
Hyperprolinemia is a rare inherited metabolic disorder characterized by a high proline level in blood and/or urine and various neuropsychiatric symptoms. Type I hyperprolinemia is caused by a proline oxidase deficiency, which is encoded by the PRODH gene on chromosome 22q11.
Mi-Ae, Jang +9 more
openaire +1 more source

Proline Intake Dampens Radiosensitivity in Prostate Cancer Cells by Targeting PRODH/MAPK Pathway

Radiation Research
Radiotherapy remains a standard treatment for prostate cancer (PCa), inducing tumor cell death and apoptosis. However, its efficacy depends on various factors, including tumor cell metabolism. In this study, we investigated whether alterations in proline metabolism influence the response of prostate cancer cells to radiation.
Lei, Chang +10 more
openaire +2 more sources

Failure to find association between PRODH deletion and schizophrenia