Results 131 to 140 of about 2,971 (153)

Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia

Archives of Medical Research, 2022
Cognitive impairment in schizophrenia (SCZ) is a core feature, relevant for the disease prognosis and functional capacity of the patients. It has also been identified as an endophenotype and proposed as a genetic mechanism of risk for schizophrenia.We aimed to evaluate the association of genetic variants in COMT, PRODH, and DISC1 with the cognitive ...
Ingrid Fricke-Galindo, Blanca E. Pérez-Aldana, Luis R. Macías-Kauffer, Susana González-Arredondo, David Dávila-Ortiz de Montellano, Carlos L. Aviña-Cervantes, Marisol López-López, Yaneth Rodríguez-Agudelo, Nancy Monroy-Jaramillo   +8 more
openaire   +2 more sources

Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia

Genes, Brain and Behavior, 2007
Haploinsufficiency of 22q11 genes including catechol‐O‐methyltransferase (COMT) and proline dehydrogenase (PRODH) may result in structural and functional brain abnormalities and increased vulnerability to schizophrenia as observed in patients with microdeletions of 22q11. Thus, COMT and PRODH could be modifier genes for schizophrenia.
Zinkstok, J., Schmitz, N., van Amelsvoort, T., Moeton, M., Baas, F., Linszen, D.   +5 more
openaire   +3 more sources

Proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia susceptibility: a meta-analysis

Metabolic Brain Disease, 2017
Previous studies have been conducted to explore the association between proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia (SZ) susceptibility, but providing the controversial results. Here we performed this meta-analysis to determine whether PRODH variants were associated with SZ risk.
Xingzhi, Guo, Peng, Tang, Caiping, Yang, Rui, Li   +3 more
openaire   +2 more sources

Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes

Journal of Psychiatric Research, 2013
22q11.2 deletion syndrome (22q11.2DS) is a common genetic risk factor for the development of schizophrenia. We investigated two neurophysiological endophenotypes of schizophrenia - P50 sensory gating and mismatch negativity in 22q11.2DS subject and evaluated their association with catechol O-methyltransferase (COMT) and proline dehydrogenase (PRODH ...
Omer, Zarchi, Miri, Carmel, Chen, Avni, Josef, Attias, Amos, Frisch, Elena, Michaelovsky, Miriam, Patya, Tamar, Green, Ronnie, Weinberger, Abraham, Weizman, Doron, Gothelf   +10 more
openaire   +2 more sources

Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects

Journal of Psychiatric Research, 2014
The 22q11.2 deletion syndrome (22q11.2DS) carries the highest genetic risk factor for the development of schizophrenia. We investigated the association of genetic variants in two schizophrenia candidate genes with executive function (EF) and IQ in 22q11.2DS individuals.
Miri, Carmel, Omer, Zarchi, Elena, Michaelovsky, Amos, Frisch, Miriam, Patya, Tamar, Green, Doron, Gothelf, Abraham, Weizman   +7 more
openaire   +2 more sources

Identification of PRODH mutations in Korean neonates with type I hyperprolinemia.

Annals of clinical and laboratory science, 2013
Hyperprolinemia is a rare inherited metabolic disorder characterized by a high proline level in blood and/or urine and various neuropsychiatric symptoms. Type I hyperprolinemia is caused by a proline oxidase deficiency, which is encoded by the PRODH gene on chromosome 22q11.
Mi-Ae, Jang, Byung Cheol, Kim, Chang-Seok, Ki, Soo-Youn, Lee, Jong-Won, Kim, Tae Youn, Choi, Dong Hwan, Lee, Junghan, Song, Yong-Wha, Lee, Hyung-Doo, Park   +9 more
openaire   +1 more source

Proline Intake Dampens Radiosensitivity in Prostate Cancer Cells by Targeting PRODH/MAPK Pathway

Radiation Research
Radiotherapy remains a standard treatment for prostate cancer (PCa), inducing tumor cell death and apoptosis. However, its efficacy depends on various factors, including tumor cell metabolism. In this study, we investigated whether alterations in proline metabolism influence the response of prostate cancer cells to radiation.
Lei, Chang, Xinzhou, Deng, Shan, Jiang, Cangyu, Wang, Jingjing, Chai, Le, Zhou, Chao, Tian, Yuanhui, Tang, Zhiguo, Luo, Lihua, Duan, Yutao, Yan   +10 more
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Failure to find association between PRODH deletion and schizophrenia

Schizophrenia Research, 2004
Tsuyuka, Ohtsuki, Syunsuke, Tanaka, Hiroki, Ishiguro, Emiko, Noguchi, Tadao, Arinami, Ei-ichi, Tanabe, Kazuo, Yara, Tatsunobu, Okubo, Sakae, Takahashi, Masato, Matsuura, Tei-ichiro, Sakai, Mariko, Muto, Takuya, Kojima, Eisuke, Matsushima, Michio, Toru, Toshiya, Inada   +15 more
openaire   +2 more sources

Importance of COMT and PRODH in psychosis development

Nature Clinical Practice Neurology, 2006
openaire   +1 more source

Schizophrenia-Like Behaviors Arising From Dysregulated Proline Metabolism Are Associated With Altered Neuronal Morphology and Function in Mice With Hippocampal PRODH Deficiency

Aging and disease, 2023
Yuxiao Yao, Weiping Han, Huanxing Su
exaly