Results 151 to 160 of about 73,102 (302)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Multiscale Modeling of an 8‐Week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients with Chronic Hepatitis C Virus Infection

Clinical Pharmacology &Therapeutics, EarlyView.
Bemnifosbuvir (BEM) and ruzasvir (RZR) are pan‐genotypic HCV polymerase (NS5B) and NS5A inhibitors, respectively. In a single‐arm study (NCT05904470), 215 treatment‐naïve, adherent participants with chronic HCV (with or without cirrhosis) received BEM 550 mg QD plus RZR 180 mg QD for 8 weeks.
Carolin Zitzmann, Ruy M. Ribeiro, Aurelien Marc, Xiao‐Jian Zhou, Alan S. Perelson   +4 more
wiley   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Trust, but Verify: Translating Dosing Evidence to Understudied Populations in Low‐ and Middle‐Income Countries

Clinical Pharmacology &Therapeutics, EarlyView.
Drug dosing recommendations derived from healthy volunteers and selected preregistration populations may not translate reliably to physiologically distinct or understudied groups, particularly in low‐ and middle‐income countries. Using a metformin–dolutegravir drug interaction study and colistin pharmacokinetic study from South Africa, we illustrate ...
Roland van Rensburg, Veshni Pillay‐Fuentes Lorente, Eric Decloedt   +2 more
wiley   +1 more source

A Nano-QSAR Model for the Cytotoxicity of Doxorubicin Prodrug Micelles in Multidrug-Resistant Cancer Cells. [PDF]

ACS Omega
Kurian S, Santiago R.
europepmc   +1 more source

Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan, Lindsey B. Collins, Christopher Staley, Flavia Kiweewa Matovu, Pamala Jacobson, Melanie Nicol, Shen Cheng   +6 more
wiley   +1 more source

Tumor Microenvironment-Triggered Dual-Prodrug Nanoplatform for Augmented Photodynamic Therapy: Self-Quenched Photosensitizer Activation and Nitric Oxide-Mediated Sensitization. [PDF]

Polymers (Basel)
Gu Y, Ding J, Zhang J, Liu X, Xu Z, Zhang J, Qu X.   +6 more
europepmc   +1 more source

Atrial natriuretic peptide modified oleate adenosine prodrug lipid nanocarriers for the treatment of myocardial infarction: in vitro and in vivo evaluation

, 2018
Jianjun Yu,1,* Wei Li,2,* Dongmei Yu3 1Department of Emergency, Shandong Jining No 1 People’s Hospital, Jining 272011, Shandong, People’s Republic of China; 2Department of Outpatient, Shandong Jining No 1 People’s Hospital, Jining ...
Li W, Yu D, Yu J
core  

Dihydropyrimidine Dehydrogenase Genotype–Phenotype Correlations in Plasma and Peripheral Blood Mononuclear Cells

Clinical Pharmacology &Therapeutics, EarlyView.
The chemotherapeutic 5‐fluorouracil (5‐FU) is commonly used to treat solid tumors, especially colorectal cancer. Deleterious variants in DPYD, which encodes dihydropyrimidine dehydrogenase (DPD), are strongly associated with severe and potentially lethal 5‐FU toxicity.
Brianna M. Bembenek, Seid Hamzic, Kelly J. Bouchonville, Carlo R. Largiadèr, Steven M. Offer   +4 more
wiley   +1 more source

Retrospective Study on the Power and Interpretation of Chiral Amphetamine Analysis in Hair for Forensic Applications

Drug Testing and Analysis, EarlyView.
A decision model for the interpretation of chiral amphetamine analysis in hair was established based on the enantiomeric fraction (EF) of (S)‐amphetamine in authentic hair samples. Two chiral analysis methods (indirect/direct) were consecutively applied to distinguish between illicit and therapeutic amphetamine use in forensic cases.
Liesl K. Janssens, Milena M. Madry, Andrea E. Steuer, Tina M. Binz   +3 more
wiley   +1 more source