Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis
iNew Medicine, EarlyView.This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang +3 more
wiley +1 more source
Liquid Compared to Solid Oral Formulations of the Thyroid Hormone Receptor Agonist Elunetirom Under Fasted and Fed Conditions in Healthy Participants. [PDF]
Clin Transl SciHarris JR +11 more
europepmc +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Organisms in human living spaces are surrounded by a variety of engineered substances. These chemical compounds have unexpected effects on the environment and human health. In particular, workers in industries face the risk of a health hazard caused by high‐dose or long‐term exposure to chemicals in the workplace.
Masahiro Tomioka
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang +3 more
wiley +1 more source
A Glutathione-Responsive Prodrug Nanosystem for Colorectal Cancer: Synergistic Co-Delivery of Paclitaxel and Curcumin to Combat Multidrug Resistance and Reinvent the Immunosuppressive Microenvironment. [PDF]
Biomater ResQiao Y +8 more
europepmc +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
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PBPK Modeling of CES1-Activated Prodrugs Across Different Age Groups: Simultaneous Prodrug-Metabolite Prediction for Oseltamivir, Enalapril, and Cilazapril. [PDF]
PharmaceuticsLi P, Yang Y, Jiang L, Wang J.
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Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
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Molecular Docking and Molecular Dynamics Studies: Evaluation of the Potential Interaction between Ciprofloxacin-DAB-PAMAM Dendrimer-Based Prodrug Prototypes and Human Carboxylesterase 1. [PDF]
ACS OmegaSueyoshi S +5 more
europepmc +1 more source
Continuous Subcutaneous Foslevodopa/Foscarbidopa in Advanced Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.Abstract Background Continuous subcutaneous foslevodopa/foscarbidopa (LDp/CDp) provides 24‐h delivery of levodopa‐carbidopa prodrugs for advanced Parkinson's disease. Real‐world 1‐year European data remain limited. Objectives To characterize 1‐year changes in motor, non‐motor, autonomic, quality‐of‐life and sleep outcomes, and in concomitant therapy ...
Mario Hero +5 more
wiley +1 more source