Results 191 to 200 of about 73,102 (302)

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Heavy-Atom-Free Dual-Action Dual PACT/PDT action Pt(IV) Prodrug With BODIPY Dimer in Axial Position. [PDF]

ChemMedChem
Bykusov V, Isaeva Y, Akasov R, Egorova T, Mun V, Bunin D, Kuzmin V, Egorov A, Burtsev I, Grishin Y, Rodin I, Vokuev M, Beloglazkina E, Krasnovskaya O.   +13 more
europepmc   +1 more source

Association of Depression and Anxiety With Postoperative Complications After Septoplasty With Turbinoplasty

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objectives Evaluate the association between comorbid depression and anxiety and postoperative complications following septoplasty with turbinoplasty, and assess whether treatment of these conditions influences surgical outcomes. Study Design Retrospective cohort study with propensity‐score matched analysis. Setting Multi‐institutional database
Amala Nayak, Iman Adibi, Suhas Rao Velichala, Michael F. Armstrong, Theodore Schuman   +4 more
wiley   +1 more source

NADPH oxidase 2 (NOX2)-independent inducers of neutrophil extracellular traps promote resolution of chronic inflammation. [PDF]

Redox Biol
Euler M, Hattab O, Borah Slater K, Golub B, Selin R, Cheng Z, Maluje Villanueva YA, Özkan GH, Bila G, Dutta K, Weidner D, Hoffmann EJ, Friscic J, Sadik CD, Harrer T, Köhl J, Schett G, Munoz L, Fähnrich A, Murthy S, Grieshaber-Bouyer R, Herrmann M, Bilyy R, Griffiths HR, Mokhir A, Hoffmann MH.   +25 more
europepmc   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Chemically Programmed Prodrug Nanoparticles for Precise Oral Dopamine Delivery to Deep Brain Regions in Parkinson's Disease. [PDF]

Adv Mater
Mac CH, Chiang YW, Nguyen HN, Wang JT, Chu LA, Lin YH, Nguyen VK, Peng SY, Lo SK, Chang Y, Nguyen MTT, Zhang QY, Lin YJ, Sung HW.   +13 more
europepmc   +1 more source

Plasma 3‐O‐Methyldopa Concentration Monitoring for Treatment Optimization in Foslevodopa/Foscarbidopa Infusion: Implications for Corrected Levodopa Availability: A Case Report

Movement Disorders Clinical Practice, EarlyView.
Shohei Okusa, Kotaro Okada, Yoshihiro Nihei, Risano Sakai, Takeshi Akiyoshi, Tomonori Nukariya, Jin Nakahara, Hisakazu Ohtani, Morinobu Seki   +8 more
wiley   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source