Results 201 to 210 of about 73,102 (302)

Covalent "Locking" of Prodrug Nanoassemblies via Thiol-Ene Click Crosslinking for Potent Antitumor Therapy. [PDF]

Adv Healthc Mater
Li X, Li L, Zhao Y, Cui J, Zhang L, Sun J, Sun B.   +6 more
europepmc   +1 more source

Suppression of PKM2 by Leonurine Attenuates Alcoholic Hepatitis Through Regulating Glycolytic Reprogramming

Phytotherapy Research, EarlyView.
Leonurine inhibits PKM2 to remodel hepatocyte glycolysis, thereby alleviating liver injury in alcoholic hepatitis. ABSTRACT Alcoholic hepatitis (AH) is a liver disease caused by long‐term heavy drinking. In the early stages, it usually manifests as fatty liver, which can then develop into liver fibrosis and cirrhosis.
Xuan‐Xuan Zhang, Gao‐Feng Pan, Hong Fang, Xiao‐Peng Liu, Jing Sun, Ji‐Xiang Chen, Xin Fan, Jia‐Hao Feng   +7 more
wiley   +1 more source

Effect of Alkyl Chain Length on Physicochemical and Pharmacokinetic Performance of Aripiprazole Fatty Acid Prodrugs for Long-Acting Injectable Suspensions. [PDF]

Pharmaceutics
Chen A, Lai C, Zhai H, Zhang S, Zhang Y, Cai T.   +5 more
europepmc   +1 more source

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source

Synthesis and Biological Evaluation of a Lipophilic Vorinostat Prodrug. [PDF]

Chem Biodivers
Thakur N, Bhardwaj N, Yadav SK, Saneja A.   +3 more
europepmc   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation. [PDF]

Adv Sci (Weinh)
Liu K, Yuan X, Zhou Y, Yuan R, Xie S, Chen Y, Wang P, Gao J, Gong Q.   +8 more
europepmc   +1 more source

Harnessing the Folding of Antitumor Peptides for Controlled Carrier‐Free Drug Delivery

Small, EarlyView.
A disulfide‐bridged stapled p53 α‐helix co‐assembled with doxorubicin into protease‐resistant nanocomplexes. Reductive intracellular conditions induced helix refolding and nanostructure disassembly, which enabled the coordinated release of the chemotherapeutic agent and anticancer peptide.
Jae Yun Lee, Moo Chang Park, Sung Chan Choi, Jieun Kim, Joo‐young Kim, Jiah Lee, Hyun Jin Kim, Kyobum Kim, Yongju Kim, Woo‐jin Jeong   +9 more
wiley   +1 more source