Results 221 to 230 of about 65,300 (300)

A reduction-sensitive lipophilic dihydroartemisinin prodrug in a self-microemulsifying drug delivery system for treating breast cancer lung metastasis via intestinal lymphatic transport. [PDF]

Int J Pharm X
Zheng B, He C, Zhao F, Li R, Zhang Z, Chen X, Shi M, He B, Wang R, Ren G, Zhang S, Yang S.   +11 more
europepmc   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Optical and Microdialysis Monitoring of Succinate Prodrug Treatment in a Rotenone-Induced Model of Mitochondrial Dysfunction in Swine. [PDF]

Metabolites
Lewis A, Forti RM, Ko TS, Elmér E, McManus MJ, Yodh AG, Kilbaugh TJ, Baker WB.   +7 more
europepmc   +1 more source

Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems

The Chemical Record, EarlyView.
Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez, Tielle Moraes de Almeida, Daiani Canabarro Leite, Gilson Zeni   +3 more
wiley   +1 more source

An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model of <i>Klebsiella pneumoniae</i> pneumonia. [PDF]

Antimicrob Agents Chemother
López CL, Rerolle G, Snyder S, Arias O, Bashmail A, Gonzalez G, Roy D, Lee B, Snyder JM, Doorn I, Baker SM, Wright SW, West TE, Skerrett SJ, Stayton PS.   +14 more
europepmc   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Iontronic click-to-release enables electrically controlled delivery of drugs and biomolecules beyond charge and size limitations. [PDF]

Nat Commun
Hecko S, Vleugels MEJ, Bayer C, Byun D, Hörberg ME, Poremba N, Boukraa R, Keppel P, Löffler A, Kuba W, Saarela Unemo H, Bernacka-Wojcik I, Arbring Sjöström T, Berggren M, Simon DT, Schindl R, Waldherr L, Mikula H, Bintinger J.   +18 more
europepmc   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

An ultra-long-acting dimeric bictegravir prodrug defined by a short pharmacokinetic tail. [PDF]

Nat Commun
Nayan MU, Sillman B, Das S, Hanson BW, Sultana A, Le NTH, Deodhar S, Gowda B, Dash PK, Agrawal S, Dash AK, Cohen SM, Zhang C, Gendelman HE, Edagwa B.   +14 more
europepmc   +1 more source