Results 211 to 220 of about 65,300 (300)

Prodrug [PDF]

, 2017
openaire   +1 more source

Alkaline Phosphatases: A Potential Cause of Variability in Therapeutic Response to Continuous Subcutaneous Foslevodopa/Foscarbidopa Infusion?

Movement Disorders, EarlyView.
Manon Auffret, Marc Vérin
wiley   +1 more source

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source

Gold-Catalyzed Carbonyl Release and its Adaptation for Prodrug Therapy Using Multivalent Lectin-Directed Artificial Metalloenzymes. [PDF]

JACS Au
Huang J, Liu Y, Li Y, Du J, Han X, Vong K.   +5 more
europepmc   +1 more source

Modular Molecular Design and Self‐Assembled Nanostructures of Saccharide‑Appended Cyclic Dipeptides for Glycosidase‑Responsive Supramolecular Hydrogels

Small, EarlyView.
Saccharide‐appended cyclic dipeptides are designed and developed as building blocks for glycosidase‐responsive supramolecular hydrogels. Their aqueous self‐assembly enables β‐galactosidase‐triggered gel‐to‐sol and neuraminidase‐triggered sol‐to‐gel transition systems, highlighting their potential as glycosidase‐responsive soft materials for biomedical ...
Shintaro Sugiura, Ryuta Tanaka, Sayuri L. Higashi, Aya Shibata, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Masato Ikeda   +6 more
wiley   +1 more source

Design of prodrugs with reactive oxygen species as activators and their application in tumor therapy. [PDF]

Theranostics
Xing J, Lu W, Zhang Y, Yang C, Yang J, Shi J, Wang Y.   +6 more
europepmc   +1 more source

A Prodrug Approach for Activity‐Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer's Disease

Small, EarlyView.
We present a pathology‐responsive, activity‐based prodrug strategy that tackles multiple hallmarks of Alzheimer's disease (AD). Rationally designed BE compounds convert under oxidative stress into redox‐active aminophenols, neutralizing ROS and redirecting both metal‐free and metal‐bound Aβ aggregation.
Jimin Lee, Eunseo Hong, Chanju Na, Yan Li, Jun Go, Ju‐Eun Kim, Hyun‐Hee Seo, Jong‐Min Suh, Jimin Kwak, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Mingeun Kim, Mi Hee Lim   +13 more
wiley   +1 more source

Redox‐responsive dual‐drug nanomedicine integrating cisplatin and trypsin for synergistic reversal of tumor chemoresistance

Smart Molecules, EarlyView.
This study presents a novel glutathione‐activatable prodrug nanomedicine (cRGD‐PEG‐PGlu‐NP (ssTrypsin & CDDP)) that co‐encapsulates cisplatin and a masked protease to combat cisplatin resistance. The dual‐drug system selectively targets resistant tumor cells, enhancing the efficacy of cisplatin while minimizing systemic toxicity.
Xiaolan Yin, Qi Wang, Ming Zhang, Cheng Zhang, Qixian Chen, Haidong Li, Yan Zhao, Yue Wang, Jingyun Wang, Liuwei Zhang, Hongyan Cui   +10 more
wiley   +1 more source

A next-generation multimetal complex induces immunogenic cell death with distinct transcriptomic signatures.

Chem Commun (Camb)
Babu T, Levine MS, Zeng B, Sessler JL.
europepmc   +1 more source