Results 101 to 110 of about 4,729,806 (295)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

From Design to Production Control Through the Integration of Engineering Data Management and Workflow Management Systems

, 1997
At a time when many companies are under pressure to reduce "times-to-market" the management of product information from the early stages of design through assembly to manufacture and production has become increasingly important.
Baker, N., Bazan, A., Bityukov, S., Chevenier, G., Estrella, F., Flour, T. Le, Goff, J-M. Le, Kovacs, Z., Lieunard, S., McClatchey, R., Murray, S., Organtini, G., Vialle, J-P.   +12 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

INNOWIZ: a guided framework for projects in industrial design education [PDF]

, 2012
This paper presents the concrete application of the INNOWIZ methodology in a design education context. This methodical philosophy is used as a structural backbone in teaching the product design process to students in industrial product design ...
Michiels, Pieter, Saldien, Jelle, Versluys, Rino, Verthé, Becky   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sustainable Design Process and Factors Considered for Product Service System [PDF]

, 2009
"Sustainability" is apparently reflected in corporate management and product development. Technology development and industrial revolution not only provide human beings luxury living quality but also causes global environmental problems and natural ...
Chuan-Ying Hsu, Jui-Che Tu
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Electropermanent Magnetic Muscles: Power‐Efficient, Low‐Voltage, Compact Magnetic Actuators to Power Wearables and Untethered Robots

Advanced Intelligent Systems
Artificial muscles are essential for advancing bio‐inspired robots, prosthetics, and wearable devices, as they enable compliant, efficient actuation without complex mechanisms.
Arturo Castillo Ugalde, Carina Carrasco, Brijesh Chavda, Thileepan Stalin, Pablo Valdivia y Alvarado   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Retracted: Research on Computer-Aided Product Design Technology. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source