Results 161 to 170 of about 1,215,540 (249)

Avoiding Product Abandonment Through User Centered Design: A Case Study Involving the Development of a 3D Printed Customized Upper Limb Prosthesis

, 2019
Amanda Coelho Figliolia, Fausto Orsi Mêdola, Frode Eika Sandnes, Ana Cláudia Tavares Rodrigues, Luís Carlos Paschoarelli   +4 more
openalex   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LCD-AHP-TRIZ methodology enhances low-carbon principles in smart product design. [PDF]

Sci Rep
Xu HZ, Chen J.
europepmc   +1 more source

From Biorefinery to Food Product Design: Peach (Prunus persica) By-Products Deserve Attention. [PDF]

Food Bioproc Tech, 2023
Rudke CRM, Zielinski AAF, Ferreira SRS.
europepmc   +1 more source

REVIEW ON DESIGN AND FABRICATION OF PROTOTYPE PRODUCT USING SOLIDWORKS AND 3D PRINTING

, 2020

openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The application of artificial intelligence-assisted technology in cultural and creative product design. [PDF]

Sci Rep
Liang J.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Perspectives on Drug Product Design Among Patients with Lung Cancer in the United Kingdom. [PDF]

Pulm Ther
Coulter JR, Baig LE, Antipas A, Montague D, Terry A, Dews SA, Ogden-Barker M, Doody C, Hauber B.   +8 more
europepmc   +1 more source

Human-computer interaction emotional design and innovative cultural and creative product design. [PDF]

Front Psychol, 2022
Gao Z, Huang J.
europepmc   +1 more source