Results 61 to 70 of about 4,729,806 (295)
Towards a change process planning tool [PDF]
, 2003 The relationship between a product and its design process is generally complex and not fully understood. When modifying a product, industry still rarely considers the implementation process and its consequences for other design activities in the company,
Clarkson, P. J., Eckert, C. M., Eger, T.
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Sustainable Value Proposition Design in a Product-Service System [PDF]
, 2012 Many companies have started to add services to their tangible products in order to defend themselves from increased competition from low-cost economies.
Kristofer Nygren, Niclas Österlind
core
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Applied SciencesDecontamination robots are becoming more common in environments where reducing human exposure to hazardous substances is essential, including healthcare settings, laboratories, and industrial cleanrooms.
Prithvi Krishna Chittoor +6 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Complex & Intelligent SystemsComplete area-coverage path planners are essential for robots performing tasks like cleaning, inspection, and surveying. However, they often involve complex calculations, mapping, and determining movement directions, leading to high computational or ...
Ash Yaw Sang Wan +4 more
doaj +1 more source
Door-Density-Aware Path Planning
IEEE AccessDoors are part of the building infrastructure that mobile robots have to pass through to reach zones on the other side. If robots were to clear these obstacles, they would require human assistance, advanced end-effectors, and complex control systems ...
Charan Vikram +6 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Towards product platform introduction: optimising commonality of components [PDF]
, 2015 Companies that design and manufacture products for a wide range of related applications need to offer the right product for each use. A platform design strategy allows designing the product range based on product platforms, where some of the components ...
Earl, Christopher +3 more
core