Results 71 to 80 of about 1,705,902 (280)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Simulation and Analysis of Different Bipolar Plate Geometrical Parameters on the Performance of PEM Fuel Cells Applying the Taguchi Method

Energies
This study examines the impact of key stamping process parameters on metallic bipolar plates for Proton Exchange Membrane Fuel Cell (PEMFC) performance using computational fluid dynamics (CFD) combined with thermal and electrochemical simulations and ...
Raquel Busqué, Matias Bossio, Enric Rovira, Albert Brigido   +3 more
doaj   +1 more source

Product and process innovation and the decision to export : firm-level evidence for Belgium [PDF]

Using data from the Community Innovation Survey for Belgium in two consecutive periods, this paper explores the relationship between firm-level innovation activities and the propensity to start exporting.
VAN BEVEREN, Ilke, VANDENBUSSCHE, Hylke
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Empirical analysis of internal social media and product innovation: Focusing on SNS and social capital [PDF]

Recently social media such as Blog and SNS has been introducing by many firms for means of sharing information inside the firm, in particular to promote product and process innovation.
Bunno, Teruyuki, Idota, Hiroki, Minetaki, Kazunori, Tsuji, Masatsugu   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Felodipine re-positioned as a neuroprotectant via improved optic nerve head blood circulation in retinal ischemic rabbits and ocular hypertensive rats

Scientific Reports
The vasodilatory and neuroprotective properties of felodipine were characterized in normal and ischemic rabbit eyes, an ocular hypertension (OHT) rat model, and cultured human neuron-like cells. Blood flow in the optic nerve head (ONH) was measured using
Takazumi Taniguchi, Takahiro Akaishi, Tatsuya Hata, Rieko Yamashita, Yoshihiko Esaki, Ryo Morofuji, Komei Okabe, Masahiro Fuwa, Yasuko Yamamoto, Li Guo, Soyoung Choi, Vy Luong, Takashi Ota, Najam A. Sharif, M. Francesca Cordeiro, Masaaki Kageyama   +15 more
doaj   +1 more source

Impacts of Incoming Knowledge on Product Innovation: Technology Transfer in Auto-related Industries in Developing Economies [PDF]

This paper studies two questions on the role of networked sources of knowledge influential to product innovation. First: What is the extent of technology transferred through vertical linkages and public-private alliances, including university-industry ...
Tomohiro MACHIKITA, Yasushi UEKI
core  

Innovations in the biodiesel production

Pressacademia, 2017
Demand on energy from alternative fuels are growing rapidly due to depletion of fossil fuels and global warming crises. Biodiesel instead of conventional petroleum diesel, is a non toxic, biodegradable and renewable fuels.  Therefore, biodiesel can be considered as a promising liquid fuel for transport sector.
Cakirca, Emine Emel, Akin, Ayse Nilgun
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source