Results 61 to 70 of about 71,507 (258)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Product Innovations in the Manafacturing Processes of Special Composites

Littera Scripta, 2017
At present, in order to maintain a sustainable production process and achieve real business competitiveness, attention needs to be paid focused planning of innovations in production systems. Major innovations are the product innovations where significant
Eva Ružinská
doaj  

A global collaboration to advance vaccine product innovations - The Vaccine Innovation Prioritisation Strategy. [PDF]

Vaccine, 2021
Kristensen D, Giersing B, Hickling J, Kazi F, Scarna T, Kahn AL, Hsu V, Gandrup-Marino K, Menozzi-Arnaud M.   +8 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

THE IMPACT OF PRODUCT AND PROCESS INNOVATION AND TECHNOLOGICAL DIMENSIONS ON THE SUSTAINABLE COMPETITIVE ADVANTAGE OF MANUFACTURING COMPANIES

Ekonomika Poljoprivrede (1979)
This study investigates the impact of product, process, and technological innovations on the sustainable competitive advantage of manufacturing companies. An empirical survey was conducted on a sample of 252 employees.
Dragana Vuković, Ana Dukić, Ana Urošević, Božo Ilić   +3 more
doaj   +1 more source

Diffusion Dynamics of Sustainable Innovation - Insights on Diffusion Patterns Based on the Analysis of 100 Sustainable Product and Service Innovations

Journal of Innovation Management, 2016
There is a growing consensus about the urgent necessity to green the economy and to decouple economic growth from environmental pressure. Against this background, the article explores three questions: (1) What are key factors influencing diffusion ...
Klaus Fichter, Jens Clausen
doaj   +1 more source

Vaccine innovation prioritisation strategy: Findings from three country-stakeholder consultations on vaccine product innovations. [PDF]

Vaccine, 2021
Mvundura M, Frivold C, Janik Osborne A, Soni P, Robertson J, Kumar S, Anena J, Gueye A, Menozzi-Arnaud M, Giersing B, Kahn AL, Scarna T, Kristensen D.   +12 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Exploring the Enablers of Organizational and Marketing Innovations in SMEs

SAGE Open, 2015
Previous research studies on innovation tend to focus on process and product innovations. Recent theoretical opinions reveal that Organizational and Marketing Innovations (OMIs) could be the necessary prerequisites to optimally utilize and deploy such ...
Oluseyi Moses Ajayi, Susan C. Morton
doaj   +1 more source

Innovations in the biodiesel production

Pressacademia, 2017
Demand on energy from alternative fuels are growing rapidly due to depletion of fossil fuels and global warming crises. Biodiesel instead of conventional petroleum diesel, is a non toxic, biodegradable and renewable fuels.  Therefore, biodiesel can be considered as a promising liquid fuel for transport sector.
Cakirca, Emine Emel, Akin, Ayse Nilgun
openaire   +3 more sources