Results 141 to 150 of about 17,831,371 (352)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Credibility Assessment for Digital Twins in Vehicle-in-the-Loop Test Based on Information Entropy
SensorsDigital twins in vehicle-in-the-loop (VIL) test has great practical significance for the functional development, testing and evaluation of intelligent vehicle.
Tianfang Gao +4 more
doaj +1 more source
Preferential Tariff Policy, Product Quality and Welfare [PDF]
optimal tariff, preferential free trade agreement, product quality, product R ...
Hur, Jung
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
What is the new paradigm in product quality? [PDF]
, 2000 The current product quality paradigm is founded upon a customer-focused product development process, in which the functionality and behaviour of a product are designed to fulfil the needs of customers, and technological innovation is used to expand the ...
Guldbrandsen, M, Robotham, AJ
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Shipin yu jixieObjectiveTo establish a method for rapid detection of 59 kinds of drugs illegally added in alcoholic products by high performance liquid chromatography-triple quadrupole mass spectrometry.MethodsAfter ultrasonic extraction of methanol-water (volume ratio
KANG Shaoying +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Complexity Analysis Approach for Prefabricated Construction Products Using Uncertain Data Clustering
, 2017 This paper proposes an uncertain data clustering approach to quantitatively analyze the complexity of prefabricated construction components through the integration of quality performance-based measures with associated engineering design information.
AbouRizk, Simaan M. +3 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source