Results 61 to 70 of about 1,374,097 (265)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Strategy of organizational-technological solutions on production of lamb for sale in farms conditions [PDF]

Ekonomika Poljoprivrede (1979), 2020
Surveys were conducted in the Nišava and Toplica districts in Serbia during 2018. The medium-sized private sheep farm (A) in Držanovac in the Toplica District and the small private sheep farm (B) in Orljan, in the Nišava District are being investigated ...
Mičić Ivan, Rajić Zoran, Halilagić Ahmet   +2 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Characterization of some archaeological ceramics and clay samples from Zamala - Far-northern part of Cameroon (West Central Africa)

Cerâmica
Seventeen ceramics samples (515±95 BP, about 580 years old) and two clay raw materials from Zamala (Far-northern, Cameroon) were characterized by X-ray diffraction (XRD), thermal analysis (DTA/TG) and X-ray fluorescence spectroscopy.
Z. L. Epossi Ntah, R. Sobott, B. Fabbri, K. Bente   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Belarusian Scientific School “Gears”

Механика машин, механизмов и материалов
Information is presented on Belarusian scientific school “Gears” (I.S. Tsitovich, O.V. Berestnev, V.B. Algin, V.E. Antonyuk etc.) from the moment of its origin in 1973 at the Joint Institute of Mechanical Engineering of the NAS of Belarus (at that time –
Victor E. Starzhinsky, Sergey V. Shil’ko, Nikolay N. Ishin   +2 more
doaj   +1 more source

Multi-criteria optimization of properties of non-woven construction thermal insulation from wool fiber [PDF]

Нанотехнологии в строительстве
Introduction. Currently, there are urgent issues of providing production facilities with domestic materials that are not inferior in quality to imported analogues. Materials for construction, including thermal insulation materials, are required for the
Konstantin E. Razumeev, Natalia A. Koroleva, Natalia E. Fedorova, Dmitry V. Sichevoy   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Soft Medical Form with Nanoparticles to Stop Bleeding: Substantiation of Composition and Technology of Obtaining

Разработка и регистрация лекарственных средств, 2019
Introduction. Due to the growth of general surgical diseases, the treatment and cessation of bleeding is an important problem of medicine and pharmacy.
Yu. N. Barsukova, O. A. Melnikova
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source