Results 101 to 110 of about 4,556 (199)

A genetic polymorphism of the endogenous opioid dynorphin modulates monetary reward anticipation in the corticostriatal loop.

PLoS ONE, 2014
The dynorphin/κ-opioid receptor (KOP-R) system has been shown to play a role in different types of behavior regulation, including reward-related behavior and drug craving.
Mikhail Votinov, Mikhail Votinov, Juergen Pripfl, Christian Windischberger, Klaudius Kalcher, Alexander Zimprich, Fritz Zimprich, Ewald Moser, Claus Lamm, Uta Sailer   +9 more
doaj   +1 more source

Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. [PDF]

, 2016
Estradiol (E2) robustly activates transcription of a broad array of genes in the hippocampal formation of middle-aged ovariectomized rats via estrogen receptors (ERalpha, ERbeta, and G protein-coupled ER).
Hrabovszky, E., Kallo, I., Liposits, Zsolt, Rodolosse, A., Sarvari, M., Solymosi, N.   +5 more
core   +1 more source

Prodynorphin-expressing neurons in the ventromedial hypothalamus respond to the predatory odor and modulate defensive behaviors

Brain Research Bulletin
The ventromedial hypothalamus (VMH) regulates stress responses and defensive behaviors. However, the neural mechanisms underlying its involvement in threat perception remain incompletely understood.
Ting He
doaj   +1 more source

Radio Electric Conveyed Fields Directly Reprogram Human Dermal Skin Fibroblasts toward Cardiac, Neuronal, and Skeletal Muscle-Like Lineages

Cell Transplantation, 2013
Somatic cells can be directly reprogrammed to alternative differentiated fates without first becoming stem/progenitor cells. Nevertheless, the initial need for viral-mediated gene delivery renders this strategy unsafe in humans. Here, we provide evidence
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna, Gianfranco Pigliaru, Sara Gualini, Claudia Cavallini, Vania Fontani, Carlo Ventura   +8 more
doaj   +1 more source

Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

PLoS ONE, 2011
A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ...
Beng-Siang Khor, Mohd Fadzly Amar Jamil, Mohamad Ilham Adenan, Alexander Chong Shu-Chien   +3 more
doaj   +1 more source

Receptors of peptides as therapeutic targets in epilepsy research [PDF]

, 2014
Neuropeptides are signaling molecules participating in the modulation of synaptic transmission. Neuropeptides are stored in dense core synaptic vesicles, the release of which requires profound excitation.
Dobolyi, A., Juhász, G., Kovács, Z., Kékesi, K. A., Lovas, G., Székely, A. D.   +5 more
core   +1 more source

Radiofrequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool for Improving Tissue Regeneration

Cell Transplantation, 2012
Radiofrequency (RF) waves from Wi-Fi (wireless fidelity) technologies have become ubiquitous, with Internet access spreading into homes, and public areas. The human body harbors multipotent stem cells with various grading of potentiality.
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna, Gianfranco Pigliaru, Sara Gualini, Vania Fontani, Carlo Ventura   +7 more
doaj   +1 more source

Expression of genes for Kisspeptin (KISS1), Neurokinin B (TAC3), Prodynorphin (PDYN), and gonadotropin inhibitory hormone (RFRP) across natural puberty in ewes

Physiological Reports, 2020
Expression of particular genes in hypothami of ewes was measured across the natural pubertal transition by in situ hybridization. The ewes were allocated to three groups (n = 4); prepubertal, postpubertal and postpubertally gonadectomized (GDX ...
Qun Li, Jeremy T. Smith, Belinda Henry, Alexandra Rao, Alda Pereira, Iain J. Clarke   +5 more
doaj   +1 more source

TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons

Molecular Metabolism, 2015
Objective: Leptin acts via its receptor (LepRb) on multiple subpopulations of LepRb neurons in the brain, each of which controls specific aspects of energy balance.
Margaret B. Allison, Christa M. Patterson, Michael J. Krashes, Bradford B. Lowell, Martin G. Myers, Jr., David P. Olson   +5 more
doaj   +1 more source

Insight into the Calmodulin and DREAM Protein Complex Interaction, Mechanism and Function [PDF]

, 2015
DREAM (Downstream regulatory element antagonistic modulator) is a neuronal calcium sensor which has been shown to modulate gene expression as well as being involved in numerous neuronal processes. In this report, we show that association of calcium bound
Gonzalez, Walter
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