Results 151 to 160 of about 3,057 (188)

Characterization of Human Prodynorphin Gene Transcripts

Biochemical and Biophysical Research Communications, 1995
Prodynorphin gene transcripts have been characterized in human tissues with cRNA probes covering parts of the non-coding exon 1 and the main coding exon 4 using Northern blot and RNase protection experiments. A 2.8-kb signal was observed in human brain RNA with both the exon 1 and exon 4 probes.
T, Geijer, M, Telkov, L, Terenius
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CREB involvement in the regulation of striatal prodynorphin by nicotine

Psychopharmacology, 2011
The transcription factor cAMP response element binding (CREB) protein plays a pivotal role in drug-dependent neuronal plasticity. CREB phosphorylation at Ser133 is enhanced by drugs of abuse, including nicotine. Dynorphin (Dyn) contributes to the addictive process and its precursor gene prodynorphin (PD) is regulated by CREB.
Michael Mccarthy, Maria Hadjiconstantinou, Norton H Neff   +2 more
exaly   +3 more sources

The Posttranslational Processing of Prodynorphin in the Rat Anterior Pituitary*

Endocrinology, 1989
The posttranslational processing of prodynorphin (Pro-Dyn) is not well understood. The rat anterior pituitary is an interesting tissue which merits examination to address this issue since it is known that Dyn immunoreactivity is stored as high mol wt (HMW) intermediates and not as free products such as dynorphin-A-(1-17) (Dyn-A17) or dynorphin-B-(1-13)
R, Day, H, Akil
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A functional prodynorphin promoter polymorphism and opioid dependence

Psychiatric Genetics, 2005
The prodynorphin gene (PDYN) promoter has a repeat polymorphism that is functionally important in association with substance abuse. We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls.Patients were selected from university-affiliated residential and non ...
Riju, Ray, Glenn A, Doyle, James J, Crowley, Russell J, Buono, David W, Oslin, Ashwin A, Patkar, Paolo, Mannelli, Peter A, DeMaria, Charles P, O'Brien, Wade H, Berrettini   +9 more
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A solution hybridization assay for the quantitation of prodynorphin mRNA

Molecular Brain Research, 1987
We have developed a RNA-RNA solution hybridization assay to quantitate the mRNA coding for prodynorphin precursor. This assay is extremely sensitive and highly specific. Using this assay we have measured the prodynorphin mRNA in various brain regions and reproductive tissues of rat.
L, Devi, J, Douglass, E, Herbert
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Prodynorphin Allelic Distribution in Scandinavian Chronic Alcoholics

Alcoholism: Clinical & Experimental Research, 1997
Two regions of the human prodynorphin gene, the exon 4‐region coding for the opioid peptides and the putative promotor/exon 1‐region were analyzed for possible presence of polymorphisms. No polymorphism was detected in the exon 4‐region, whereas a GC/AT base‐pair exchange was observed 301 base pairs upstream of the exon 1/intron A boundary.
T, Geijer, E, Jönsson, J, Neiman, A, Gyllander, G, Sedvall, U, Rydberg, L, Terenius   +6 more
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Regulation of prodynorphin gene expression in the hippocampus by glucocorticoids

Molecular Brain Research, 1992
The regulation of prodynorphin gene expression by glucocorticoids in the hippocampus was examined in rats that were adrenalectomized (ADX) either 7, 30, 60 and 90 days prior to sacrifice. Peptide levels in the hippocampus of ADX rats were determined by radioimmunoassay and immunocytochemistry.
L, Thai, P H, Lee, J, Ho, H, Suh, J S, Hong   +4 more
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Prodynorphin storage and processing in axon terminals and dendrites

The FASEB Journal, 2006
The classical view postulates that neuropeptide precursors in neurons are processed into mature neuropeptides in the somatic trans ‐Golgi network (TGN) and in secretory vesicles during axonal transport.
Tatiana Yakovleva, Igor Bazov, Gvido Cebers, Zoya Marinova, Yuko Hara, Aisha Ahmed, Mila Vlaskovska, Björn Johansson, Ute Hochgeschwender, Indrapal N. Singh, Annadora J. Bruce‐Keller, Yasmin L. Hurd, Takeshi Kaneko, Lars Terenius, Tomas J. Ekström, Kurt F. Hauser, Virginia M. Pickel, Georgy Bakalkin, Tatiana Yakovleva, Igor Bazov, Gvido Cebers, Zoya Marinova, Yuko Hara, Aisha Ahmed, Mila Vlaskovska, Björn Johansson, Ute Hochgeschwender, Indrapal N. Singh, Annadora J. Bruce‐Keller, Yasmin L. Hurd, Takeshi Kaneko, Lars Terenius, Tomas J. Ekström, Kurt F. Hauser, Virginia M. Pickel, Georgy Bakalkin   +35 more
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Trends in the Evolution of the Proenkephalin and Prodynorphin Genes in Gnathostomes

Annals of the New York Academy of Sciences, 2005
Abstract: The opioid/orphanin gene family provides a model system for analyzing the outcomes of genome duplication events. Recent studies on the proenkephalin gene provide additional evidence that the organizational plan for this gene has been conserved throughout the extensive radiation of the gnathostome vertebrates.
Ashley, Khalap, Brian, Bagrosky, Stephanie, Lecaude, John, Youson, Phillip, Danielson, Robert M, Dores   +5 more
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Prodynorphin Biosynthesis and Posttranslational Processing

1993
In 1979 Goldstein and colleagues (Goldstein et al. 1979) reported the characterization and partial sequence of a highly potent endogenous opioid peptide, obtained from pituitary extracts, that contained the amino acid sequence for leu-enkephalin at its amino-terminus (this peptide was found to be 17 amino acids in length when sequencing was completed ...
R. Day, K. A. Trujillo, H. Akil
openaire   +1 more source