Results 161 to 170 of about 3,057 (188)
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Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum
Psychopharmacology, 2008Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) contributes to the behavioral pharmacology of ...
ISOLA, RAFFAELLA +4 more
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Allelic Variation in the Human Prodynorphin Gene Promoter and Schizophrenia
Neuropsychobiology, 2002Experimental and clinical studies suggest an involvement of the opioid neuropeptide system in schizophrenia. In particular, the prodynorphin (PDYN), the precursor of the dynorphin opioid peptides, has been shown to play an important role in several aspects of human mental diseases.
M. Ventriglia +6 more
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C-Jun activation of the DYNCRE3 site in the prodynorphin promoter
Molecular Brain Research, 1996The DYNCRE3 site in the prodynorphin promoter is similar to both the AP-1 and cAMP-responsive element (CRE) consensus sequences. Because c-Jun is known to bind to both AP-1 and CRE sequences, we evaluated the potential role of this transcription factor at the DYNCRE3 site using transient transfection and gel mobility shift analyses.
D J, Messersmith +4 more
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Prodynorphin-Derived Opioid Peptides
2006The dynorphin family is composed of multiple peptides. They are distributed in the central nervous system and peripheral tissues. Dynorphins dusply several biological functions, including the regulation of pain transmission, feeding, pituitary hormone release, and they may affect the myocardial function.
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Species-Specific Processing of Prodynorphin in the Posterior Pituitary of Mammals*
Endocrinology, 1987The steady state levels of the prodynorphin-derived opioid peptides, dynorphin A, dynorphin B, and alpha-neo-endorphin, have been extensively studied in the magnocellular/posterior pituitary system of the rat. To determine whether the rat system serves as a general model for prodynorphin processing in the mammalian posterior pituitary, we examined the ...
R M, Dores, H, Akil
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Elevated prodynorphin expression associated with ethanol withdrawal convulsions
Neurochemistry International, 2000The hypothesis that kappa-opioid system activity may in part mediate convulsions exhibited during ethanol withdrawal was tested by exposing Withdrawal Seizure-Prone (WSP) and Withdrawal Seizure-Resistant (WSR) mice to chronic ethanol. Whole brain was harvested for RNA isolation and prodynorphin mRNA steady-state levels in whole brain were examined ...
A S, Beadles-Bohling +2 more
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Dynorphin and prodynorphin mRNA changes in the striatum during nicotine withdrawal
Synapse, 2008Abstract Nicotine withdrawal causes somatic and negative affective symptoms that contribute to relapse and continued tobacco smoking. So far, the neuronal substrates involved are not fully understood, and an opioid role has been suggested. In this regard, the opioid dynorphin (Dyn) is of interest as it produces aversive states and has
ISOLA, RAFFAELLA +4 more
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A processing enzyme for prodynorphin derived peptides.
NIDA research monograph, 1988Endo-oligopeptidase A known to hydrolyse the Phe5-Ser6 bond of bradykinin and the Arg8-Arg9 bond of neurotensin has been shown to produce, by a single cleavage, leucine5-enkephalin from small prodynorphin derived enkephalin-containing peptides. The specificity constants (kcat/km) obtained for the hydrolysis of bradykinin, neurotensin and dynorphin B ...
K M, Metters +4 more
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Chromosomal localization of the human proenkephalin and prodynorphin genes.
American journal of human genetics, 1988DNA probes derived from rat and human proenkephalin and prodynorphin genes have been used to localize these two opiate neuropeptide genes on human chromosomes. Hybridization of probes to Southern blots made with DNAs from a rodent-human somatic-cell hybrid panel indicates localization of proenkephalin to human chromosome 8 and of prodynorphin to human ...
M, Litt +6 more
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