Results 171 to 180 of about 4,556 (199)

Elevated prodynorphin expression associated with ethanol withdrawal convulsions

Neurochemistry International, 2000
The hypothesis that kappa-opioid system activity may in part mediate convulsions exhibited during ethanol withdrawal was tested by exposing Withdrawal Seizure-Prone (WSP) and Withdrawal Seizure-Resistant (WSR) mice to chronic ethanol. Whole brain was harvested for RNA isolation and prodynorphin mRNA steady-state levels in whole brain were examined ...
A S, Beadles-Bohling, J C, Crabbe, K M, Wiren   +2 more
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Proenkephalin and prodynorphin related neuropeptides in the cochlea

Hearing Research, 1985
Dynorphin B (rimorphin), a proenkephalin B (prodynorphin)-derived peptide, and met-enkephalin-Arg6, Gly7, Leu8 (met-enkephalin octapeptide), a proenkephalin A-derived peptide, were identified in the mammalian cochlea by specific radioimmunoassays. The antisera are directed against unique sequences in the peptides, and this immunoreactivity cannot be ...
D W, Hoffman, N, Zamir, J A, Rubio, R A, Altschuler, J, Fex   +4 more
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A functional prodynorphin promoter polymorphism and opioid dependence

Psychiatric Genetics, 2005
The prodynorphin gene (PDYN) promoter has a repeat polymorphism that is functionally important in association with substance abuse. We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls.Patients were selected from university-affiliated residential and non ...
Riju, Ray, Glenn A, Doyle, James J, Crowley, Russell J, Buono, David W, Oslin, Ashwin A, Patkar, Paolo, Mannelli, Peter A, DeMaria, Charles P, O'Brien, Wade H, Berrettini   +9 more
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Prodynorphin Biosynthesis and Posttranslational Processing

1993
In 1979 Goldstein and colleagues (Goldstein et al. 1979) reported the characterization and partial sequence of a highly potent endogenous opioid peptide, obtained from pituitary extracts, that contained the amino acid sequence for leu-enkephalin at its amino-terminus (this peptide was found to be 17 amino acids in length when sequencing was completed ...
R. Day, K. A. Trujillo, H. Akil
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Human prodynorphin gene generates several tissue-specific transcripts

Brain Research, 1998
The present study analyzes the transcription of the human prodynorphin gene. Transfection experiments indicate that promoter activity for the 2.8 kb 'brain-type' human prodynorphin mRNA resides in the DNA region located 140-180 b upstream of the exon 1/intron A boundary and not 1.2 kb further upstream, as proposed by others [S. Horikawa, T.
M, Telkov, T, Geijer, L, Terenius
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Prodynorphin gene expression relates to NF-κB factors

Molecular Brain Research, 1994
The prodynorphin gene contains several kappa B motifs, suggesting that kappa B-specific DNA-binding factors may regulate its expression. Prodynorphin is known to be expressed in human tumor cell lines [Geiger et al., Regul. Peptides, 34 (1991) 181-188] and we report here that several DNA-binding factors of the NF-kappa B/c-Rel-family are present in the
G, Bakalkin, T, Yakovleva, L, Terenius
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Prodynorphin-Derived Opioid Peptides

2006
The dynorphin family is composed of multiple peptides. They are distributed in the central nervous system and peripheral tissues. Dynorphins dusply several biological functions, including the regulation of pain transmission, feeding, pituitary hormone release, and they may affect the myocardial function.
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Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression

American Journal of Physiology-Endocrinology and Metabolism, 2006
Calcium-binding proteins regulate transcription and secretion of pancreatic islet hormones. Here, we demonstrate neuroendocrine expression of the calcium-binding downstream regulatory element antagonistic modulator (DREAM) and its role in glucose-dependent regulation of prodynorphin (PDN) expression.
David A, Jacobson, Julie, Cho, Luis R, Landa, Natalia A, Tamarina, Michael W, Roe, Joseph D, Buxbaum, Louis H, Philipson   +6 more
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Cloning of Prodynorphin cDNAs from the Brain of Australian and African Lungfish: Implications for the Evolution of the Prodynorphin Gene

Neuroendocrinology, 2004
In mammals the opioids Met-enkephalin and Leu-enkephalin are derived from a common precursor, proenkephalin, and as a result these neuropeptides are co-localized in enkephalinergic neurons. The mammalian scheme for enkephalinergic networks is not universal for all classes of sarcopterygian vertebrates.
Robert M, Dores, Cristina, Sollars, Stephanie, Lecaude, Jenny, Lee, Phillip, Danielson, Jasem, Alrubaian, Isabelle, Lihrman, Jean M P, Joss, Hubert, Vaudry   +8 more
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Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum

Psychopharmacology, 2008
Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) contributes to the behavioral pharmacology of ...
ISOLA, RAFFAELLA, ZHANG H, TEJWANI G. A, NEFF N. H, HADJICONSTANTINOU M.   +4 more
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