Results 91 to 100 of about 6,148,103 (286)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Impact of dicarboxystilbene impurities on the properties of swift heavy ion latent tracks in PET films

Optical Materials: X
We present a new hypothesis and supporting experimental evidence about the essential role played by small impurities of dicarboxystilbene in the process of UV treatment of PET films irradiated with swift heavy ions (SHI). This treatment both forms highly
Adil Z. Tuleushev, Fiona E. Harrison, Artem L. Kozlovskiy, Maxim V. Zdorovets   +3 more
doaj   +1 more source

INTEGRATION ANALYSIS OF THE ENTERPRISE'S EXTERNAL ENVIRONMENT AND INTERNAL CAPACITY

Вестник Северо-Кавказского федерального университета, 2022
The article sets as the goal on the basis of the integration analysis of the external environment and the internal capacity of the enterprise to develop a number of targets that can serve as the basis for the formation and subsequent implementation of ...
E. Depershmidt
doaj  

bettercallsal: better calling of Salmonella serotypes from enrichment cultures using shotgun metagenomic profiling and its application in an outbreak setting [PDF]

, 2023
Kranti Konganti, Elizabeth Reed, Mark K. Mammel, Tunc Kayikcioglu, Rachel Binet, Karen G. Jarvis, Christina M. Ferreira, Rebecca Bell, Jie Zheng, Amanda Windsor, Andrea Ottesen, Christopher J. Grim, Padmini Ramachandran   +12 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Annealing-Driven Recrystallization of Mechanically Deformed Ce-Doped ZrO₂ Ceramics

Crystals
During the annealing, recrystallization processes in ceramics can occur, manifested in the formation of new grains, grain-boundary migration, and grain coarsening.
Natalia O. Volodina, Rafael I. Shakirzyanov   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Kinome profiling of peripheral blood mononuclear cells collected prior to vaccination reveals biomarkers and potential mechanisms of vaccine unresponsiveness in pigs [PDF]

, 2020
Sean Lipsit, James Wilkinson, Erin Scruten, Antonio Facciuolo, Connor Denomy, Philip Griebel, Anthony Kusalik, Graham Plastow, Scott Napper   +8 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source