Results 91 to 100 of about 4,280,758 (253)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Una mirada retrospectiva y hacia el futuro para fortalecer la revista Profile
, 2020 Last February we held the XV PROFILE Symposium, an annual local event aimed at inviting teachers of English from different backgrounds to reflect on our profession, to share research results and innovations, and to highlight the importance of doing ...
Nieto-Cruz, María Claudia +1 more
core +1 more source
Scientific ReportsBiogenic hydroxyapatite (HAp)–TiO2 composites were synthesized from waste eggshells and seashells as calcium precursors and evaluated as sustainable photocatalysts for organic pollutant degradation.
Heejin Yang +7 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Conocimiento de los profesores acerca de la segunda lengua y el currículo: una experiencia narrativa
, 2011 23 páginasThis study was carried out with a group of three teachers who work for the foreign languages de- partment of a private university in Colombia.
Mendieta Aguila, Jenny Alexandra
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INTEGRATION ANALYSIS OF THE ENTERPRISE'S EXTERNAL ENVIRONMENT AND INTERNAL CAPACITY
Вестник Северо-Кавказского федерального университета, 2022 The article sets as the goal on the basis of the integration analysis of the external environment and the internal capacity of the enterprise to develop a number of targets that can serve as the basis for the formation and subsequent implementation of ...
E. Depershmidt
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Accumulative index of published articles in PROFILE Vol. 14 (2012)
, 2012 Accumulative index of published articles in PROFILE Vol.
Cárdenas B., Melba Libia
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