Results 111 to 120 of about 7,503,639 (285)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Optical Materials: XWe present a new hypothesis and supporting experimental evidence about the essential role played by small impurities of dicarboxystilbene in the process of UV treatment of PET films irradiated with swift heavy ions (SHI). This treatment both forms highly
Adil Z. Tuleushev +3 more
doaj +1 more source
INTEGRATION ANALYSIS OF THE ENTERPRISE'S EXTERNAL ENVIRONMENT AND INTERNAL CAPACITY
Вестник Северо-Кавказского федерального университета, 2022 The article sets as the goal on the basis of the integration analysis of the external environment and the internal capacity of the enterprise to develop a number of targets that can serve as the basis for the formation and subsequent implementation of ...
E. Depershmidt
doaj
Extracting the Italian output gap: a Bayesian approach [PDF]
, 2014 During the last decades particular effort has been directed towards understanding and predicting the relevant state of the business cycle with the objective of decomposing permanent shocks from those having only a transitory impact on real output.
Bernardi, Mauro, Di Ruggiero, Antonio
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Game interpretation of Kolmogorov complexity [PDF]
, 2010 The Kolmogorov complexity function K can be relativized using any oracle A, and most properties of K remain true for relativized versions. In section 1 we provide an explanation for this observation by giving a game-theoretic interpretation and showing ...
Alexander Shen +6 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Annealing-Driven Recrystallization of Mechanically Deformed Ce-Doped ZrO2 Ceramics
CrystalsDuring the annealing, recrystallization processes in ceramics can occur, manifested in the formation of new grains, grain-boundary migration, and grain coarsening.
Natalia O. Volodina +1 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source