Results 31 to 40 of about 1,598 (268)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Educación y crianza de los hijos. Detección de necesidades socioeducativas y formativas de los progenitores.

Revista Española de Pedagogía, 2021
Los progenitores se preguntan en multitud de ocasiones qué y cómo proceder ante las diferentes situaciones surgidas con sus hijos. A estas cuestiones intentan dar respuesta los programas de educación parental (PEP).
Francisco José Rubio Hernández, Carmen Jiménez Fernández, María Paz Trillo Miravalles   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Quarenta e oito anos de melhoramento da videira em São Paulo, Brasil Forty eigth years of grape breeding in São Paulo, Brazil

Scientia Agricola, 1995
A cultura de uvas de mesa em São Paulo vem aumentando de importância, o que é flagrante pelos incrementos na área plantada verificados nos últimos anos.
C.P. Ferri, C.V. Pommer
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

DESEMPEÑO REPRODUCTIVO DE PROGENITORES CULTIVADOS DE Litopenaeus schmitti EN SISTEMAS DE TANQUES UNISEXOS Y MIXTOS EN CONDICIONES COMERCIALES.

Revista de Investigaciones Marinas, 2023
Los Laboratorios de Producción de Postlarvas requieren de un aumento del porcentaje de cópulas en reproductores obtenidos en ciclo cerrado, para poder satisfacer la demanda de postlarvas de las granjas camaroneras. En este trabajo se evalúa el desempeño
Lourdes Pérez-Jar, Laida Ramos, Ilie S. Racotta, Claribel Guerrero, Alexander Acebedo   +4 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The progenitor of the Vela pulsar [PDF]

Monthly Notices of the Royal Astronomical Society, 2022
ABSTRACTWith Gaia parallaxes, it is possible to study the stellar populations associated with individual Galactic supernova remnants (SNRs) to estimate the mass of the exploding star. Here, we analyse the luminous stars near the Vela pulsar and SNR to find that its progenitor was probably ($\mathrel {\raise.3ex\rm{\gt }\lower0.6ex\rm{\sim }}90\rm \,per\
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source